Somova L, Mufunda J
Department of Physiology, University of Zimbabwe, Mount Pleasant, Harare.
Clin Exp Hypertens. 1993 Sep;15(5):781-96. doi: 10.3109/10641969309041641.
Black essential hypertensive patients with a mean arterial pressure of 125 +/- 3 mm Hg (mean +/- SEM), and age and sex matched normotensive subjects with a mean arterial pressure of 89 +/- 2 mm Hg were studied under baseline conditions, after five days of salt restriction and after five days of salt loading. Salt sensitivity was defined as an increase of mean blood pressure exceeding 5% when progressing from low to high sodium intake. In vitro platelet responsiveness was assessed by aggregometry, and in vitro platelet activity by estimation of beta-thromboglobulin (BTG) in plasma and thromboxane B2 (TXB2) excretion rate. Salt sensitivity was present in 66% of hypertensive and 55% of the normotensive subjects. An increased platelet aggregability to ADP (25%), to epinephrine (34%) and to collagen (12%) was found in parallel with an increased in vivo platelet activity (BTG increased by 55% and TXB2 by 18%) in the hypertensives. All changes were significantly exaggerated in the salt sensitive as compared to salt resistant hypertensive patients.
研究了平均动脉压为125±3mmHg（均值±标准误）的黑人原发性高血压患者，以及年龄和性别匹配、平均动脉压为89±2mmHg的血压正常受试者，研究在基线条件下、限盐五天后和高盐饮食五天后进行。盐敏感性定义为从低钠摄入过渡到高钠摄入时平均血压升高超过5%。通过血小板聚集测定评估体外血小板反应性，通过估计血浆中的β-血小板球蛋白（BTG）和血栓素B2（TXB2）排泄率评估体外血小板活性。66%的高血压患者和55%的血压正常受试者存在盐敏感性。在高血压患者中，发现血小板对ADP（增加25%）、肾上腺素（增加34%）和胶原（增加12%）的聚集性增加，同时体内血小板活性增加（BTG增加55%，TXB2增加18%）。与盐抵抗性高血压患者相比，盐敏感性高血压患者的所有变化都明显更显著。
