Heller J, Hellerová S, Dobesová Z, Kunes J, Zicha J
Institute for Clinical and Experimental Medicine, Czech Academy of Sciences, Prague.
Clin Exp Hypertens. 1993 Sep;15(5):807-18. doi: 10.3109/10641969309041643.
Several animal models of genetic hypertension have been developed but not all of them possess a closely related control strain. Therefore, a new model based on Wistar rats is described in which both hypertensive and normotensive lines were bred from a single parental pair. Several basic data on the two lines (called the Prague Hypertensive Rat, PHR, and the Prague Normotensive Rat, PNR) are given. PNR had a longer survival compared with PHR. At the age of 7 weeks, systolic blood pressure was 161 +/- 14 mmHg in PHR males and 109 +/- 9 mmHg in PNR males. Its further increase with age was very slow in PNR but very steep in PHR. Typical left ventricular cardiac hypertrophy developed in PHR in which cardiac output was not significantly different from that of PNR but total peripheral resistance was higher. Kidney weight was also greater in PHR than in PNR. There was no difference in basic renal functions except of proteinuria which was higher in PHR than in PNR. No differences were observed in extracellular and interstitial fluid volumes whereas plasma and blood volumes were slightly but significantly greater in PHR than in PNR suggesting a shift of extracellular fluid towards the intravascular compartment. This hypertensive model the parameters of which resemble to those of human essential hypertension should be especially suitable for cross-transplantation studies.
已经建立了几种遗传性高血压动物模型，但并非所有模型都有密切相关的对照品系。因此，本文描述了一种基于Wistar大鼠的新模型，其中高血压和正常血压品系均由一对亲本培育而来。给出了这两个品系（称为布拉格高血压大鼠，PHR，和布拉格正常血压大鼠，PNR）的一些基础数据。与PHR相比，PNR的生存期更长。7周龄时，PHR雄性大鼠的收缩压为161±14 mmHg，PNR雄性大鼠为109±9 mmHg。随着年龄增长，PNR的收缩压进一步升高非常缓慢，而PHR则非常迅速。PHR出现典型的左心室心肌肥厚，其心输出量与PNR无显著差异，但总外周阻力更高。PHR的肾脏重量也比PNR大。除蛋白尿外，基本肾功能无差异，PHR的蛋白尿高于PNR。细胞外液和组织间液体积无差异，而PHR的血浆和血容量略高于PNR且差异显著，提示细胞外液向血管内间隙转移。这种高血压模型的参数与人原发性高血压相似，应特别适合于交叉移植研究。
