Heller J, Havlícková J, Hellerová S, Schubert G, Thurau K
Institute of Clinical Experimental Medicine, Prague, Czech Republic.
Kidney Int Suppl. 1996 Jun;55:S163-5.
Using the Prague hypertensive rat (PHR), a model derived from the Wistar rat, in which a normotensive parallel, the Prague normotensive rat (PNR), was bred from the same parent pair (so that transplantation of organs between both these parallel rat model lines results in no distinct signs of rejection), we were able to show that hypertension travels with the kidney. Transplantation of a kidney from PHR to a bilaterally nephrectomized (BNX) PNR led to an increase in systolic blood pressure (SBP) in the recipient for 10 weeks after grafting. Similarly, a decrease in SBP was seen in BNX PHR for the same period of time after grafting a kidney from PNR. If, however, the SBP was measured over a longer period of time, because the elevated SBP slowly drops after grafting a kidney from PHR to BNX PNR, it is less than 130 mm Hg in the fourth month and thereafter. If BNX PHR receives a kidney from PNR, the decrease in SBP is permanent, amounting to 126.3 +/- 12.7 mm Hg one year after transplantation. The grafting of a heart from PHR to the abdominal aorta of PNR does not influence SBP. In conclusion, the presence of a kidney from PHR is necessary for the development, but is not sufficient for the maintenance of hypertension. The heart of PHR is not "hypertensogenic" as is the kidney.
利用源自Wistar大鼠的布拉格高血压大鼠（PHR），在同一亲代配对中培育出一种血压正常的平行模型——布拉格血压正常大鼠（PNR）（这样在这两个平行大鼠模型品系之间进行器官移植不会产生明显的排斥迹象），我们能够证明高血压与肾脏相关。将PHR的肾脏移植到双侧肾切除（BNX）的PNR体内，会导致受体在移植后10周内收缩压（SBP）升高。同样，在将PNR的肾脏移植到BNX的PHR体内后的同一时间段内，可观察到SBP下降。然而，如果在更长时间内测量SBP，由于将PHR的肾脏移植到BNX的PNR体内后升高的SBP会缓慢下降，在第四个月及之后会低于130 mmHg。如果BNX的PHR接受PNR的肾脏，SBP的下降是永久性的，移植一年后降至126.3±12.7 mmHg。将PHR的心脏移植到PNR的腹主动脉不会影响SBP。总之，PHR的肾脏的存在对于高血压的发生是必要的，但对于高血压的维持并不充分。PHR的心脏不像其肾脏那样具有“致高血压性”。
