绵羊的布鲁拉繁殖力基因（FecB）与人类4号染色体q区域的标记相关联。
The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q.
作者信息
Montgomery G W, Crawford A M, Penty J M, Dodds K G, Ede A J, Henry H M, Pierson C A, Lord E A, Galloway S M, Schmack A E
机构信息
Department of Biochemistry, University of Otago, Dunedin, New Zealand.
出版信息
Nat Genet. 1993 Aug;4(4):410-4. doi: 10.1038/ng0893-410.
The autosomal Booroola fecundity gene (FecB) mutation in sheep increases ovulation rate and litter size, with associated effects on ovarian physiology and hormone profiles. Analysis of segregation in twelve families (379 female progeny) identified linkage between the mutation, two microsatellite markers (OarAE101 and OarHH55, Zmax > 9.0) and epidermal growth factor (EGF) from human chromosome 4q25 (Zmax > 3.0). The marker OarAE101 was linked to secreted phosphoprotein 1 (SPP1, which maps to chromosome 4q21-23 in man) in the test pedigrees and independent families (Zmax > 9.7). The identification of linkage between the FecB mutation and markers from human chromosome 4q is an important step towards further understanding the control of ovulation rates in mammals.
绵羊中的常染色体布鲁拉繁殖力基因（FecB）突变会提高排卵率和产仔数，并对卵巢生理和激素水平产生相关影响。对12个家系（379只雌性后代）的分离分析确定了该突变、两个微卫星标记（OarAE101和OarHH55，Zmax>9.0）与人4号染色体q25上的表皮生长因子（EGF，Zmax>3.0）之间的连锁关系。在测试家系和独立家系中，标记OarAE101与分泌磷蛋白1（SPP1，在人类中定位于4号染色体q21 - 23）连锁（Zmax>9.7）。FecB突变与人类4号染色体q上标记之间连锁关系的确定是进一步了解哺乳动物排卵率控制的重要一步。
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