Del Rio G, Verlardo A, Zizzo G, Marrama P, Della Casa L
Department of Endocrinology and Metabolism, University of Modena, Italy.
Int J Obes Relat Metab Disord. 1993 Aug;17(8):465-9.
Sex-related differences both in the basal secretion of catecholamines and in the adrenergic reactivity to various stimuli have been described. We studied the responses of catecholamines and arterial blood pressure to clonidine (0.3 mg per os) in 31 normotensive subjects (10 men (M), aged 18-42 years, and 21 women (W), aged 20-48 years). Plasma catecholamines were determined by HPLC at -30, -15, 0, 120, 130, 140 min after clonidine. The basal levels of plasma norepinephrine were similar in men and in women (M = 1.16 +/- 0.26 vs. W = 0.87 +/- 0.07 nmol/l). Basal plasma epinephrine levels were not different in the two sexes (M = 0.21 +/- 0.03 vs. W = 0.14 +/- 0.03 nmol/l). The mean arterial pressure decrease after clonidine was similar in the two groups (M = 13 +/- 3 vs. W = 15 +/- 2 mmHg). The decrease in plasma epinephrine after clonidine was similar in men and women (M = 0.06 +/- 0.04 vs. W = 0.09 +/- 0.02 nmol/l). In contrast, the plasma levels of norepinephrine after clonidine were reduced more in women than in men either when expressed as absolute values (W = 0.63 +/- 0.07 vs. M = 0.3 +/- 0.1 nmol/l; F = 7.6, P < 0.02) or as percentage change (W = 71 +/- 3 vs. M = 34 +/- 8; P < 0.002). The present study demonstrates that an elevated alpha 2-adrenergic activity in women may be responsible for the sexual dimorphism in catecholamine secretion.
已有研究描述了儿茶酚胺基础分泌以及对各种刺激的肾上腺素能反应性方面的性别差异。我们对31名血压正常的受试者（10名男性，年龄18 - 42岁；21名女性，年龄20 - 48岁）进行了研究，观察他们对可乐定（口服0.3毫克）的儿茶酚胺和动脉血压反应。在服用可乐定后的-30、-15、0、120、130、140分钟，通过高效液相色谱法测定血浆儿茶酚胺。男性和女性的血浆去甲肾上腺素基础水平相似（男性 = 1.16 ± 0.26与女性 = 0.87 ± 0.07纳摩尔/升）。两性的血浆肾上腺素基础水平无差异（男性 = 0.21 ± 0.03与女性 = 0.14 ± 0.03纳摩尔/升）。两组服用可乐定后平均动脉压的下降相似（男性 = 13 ± 3与女性 = 15 ± 2毫米汞柱）。男性和女性服用可乐定后血浆肾上腺素的下降相似（男性 = 0.06 ± 0.04与女性 = 0.09 ± 0.02纳摩尔/升）。相比之下，服用可乐定后，无论是以绝对值表示（女性 = 0.63 ± 0.07与男性 = 0.3 ± 0.1纳摩尔/升；F = 7.6，P < 0.02）还是以百分比变化表示（女性 = 71 ± 3与男性 = 34 ± 8；P < 0.002），女性血浆去甲肾上腺素水平的降低都比男性更多。本研究表明，女性α2 - 肾上腺素能活性升高可能是儿茶酚胺分泌性别差异的原因。
