Lalani T, Simmons R K, Ahmed A R
Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, Massachusetts 02112, USA.
Ann Allergy Asthma Immunol. 1999 Apr;82(4):317-32; quiz 332-3. doi: 10.1016/S1081-1206(10)63281-4.
Reading this article will increase the readers' knowledge of the biology of interleukin-5 (IL-5), an important cytokine. The immune and inflammatory responses of any organism are the basis of the defense mechanism ensuring its survival. The role of IL-5 in these processes, as well as in the pathogenesis of various diseases has been discussed along with the effects of various pharmacologic agents on the production and function of IL-5.
A detailed literature search was performed. Studies considered relevant and important, in all languages, which involved humans and animals were used.
Information was obtained only from peer reviewed journals.
Interleukin-5 is normally produced by T-cells, mast cells, and eosinophils while Reed Sternberg and Epstein Barr virus (EBV) transformed cells also produce IL-5. Monoclonal antibodies (mAb) to IL-5 are potent inhibitors of IL-5 mediated tissue damage, secondary to eosinophil infiltration. The majority of the studies on IL-5 are preliminary, often the information is obtained from animal studies or in vitro systems and occasionally from pathologic tissue analysis. This along with the absence of confirmatory studies is a limiting factor. Nonetheless, the role of IL-5 in allergic and immunologic disease and asthma may be central to their pathogenesis.
Interleukin-5 is an important molecule that is participant to many processes that maintain health and are involved directly or indirectly in the pathogenesis of disease. Some pharmacologic agents can modify IL-5 production in vivo. Development of selective inhibitors of IL-5 may have a potential use for specific therapy of certain autoimmune, inflammatory, and neoplastic diseases.
阅读本文将增加读者对白细胞介素-5（IL-5，一种重要的细胞因子）生物学特性的了解。任何生物体的免疫和炎症反应都是确保其生存的防御机制的基础。本文讨论了IL-5在这些过程以及各种疾病发病机制中的作用，同时也探讨了各种药物制剂对IL-5产生和功能的影响。
进行了详细的文献检索。使用了所有语言的、涉及人类和动物的、被认为相关且重要的研究。
仅从同行评审期刊获取信息。
白细胞介素-5通常由T细胞、肥大细胞和嗜酸性粒细胞产生，而里德·施特恩伯格细胞和爱泼斯坦-巴尔病毒（EBV）转化细胞也能产生IL-5。针对IL-5的单克隆抗体（mAb）是IL-5介导的、继发于嗜酸性粒细胞浸润的组织损伤的有效抑制剂。大多数关于IL-5的研究都是初步的，信息通常来自动物研究或体外系统，偶尔来自病理组织分析。再加上缺乏验证性研究，这是一个限制因素。尽管如此，IL-5在过敏性和免疫性疾病以及哮喘中的作用可能是其发病机制的核心。
白细胞介素-5是一个重要的分子，参与维持健康的许多过程，并直接或间接参与疾病的发病机制。一些药物制剂可以在体内改变IL-5的产生。开发IL-5的选择性抑制剂可能对某些自身免疫性、炎症性和肿瘤性疾病的特异性治疗具有潜在用途。
