Hirose H, Hirose K, Isogai E, Miura H, Ueda I
Department of Preventive Dentistry, School of Dentistry, Higashi Nippon Gakuen University, Hokkaido, Japan.
Caries Res. 1993;27(4):292-7. doi: 10.1159/000261553.
Three hundred and thirty-eight children (age range 3-5 years) were examined for the presence of mutans streptococci in their saliva. They were divided into four groups according to the prevalent species that were isolated: (1) Streptococcus mutans and Streptococcus sobrinus group (S. mutans > or = 10(3) CFU/ml and S. sobrinus > or = 10(3) CFU/ml); (2) S. mutans group (S. mutans > or = 10(3) CFU/ml but S. sobrinus < 10(3) CFU/ml); (3) S. sobrinus group (S. sobrinus > or = 10(3) CFU/ml but S. mutans < 10(3) CFU/ml), and (4) children with mutants streptococci absent or barely detectable (mutants streptococci < 10(3) CFU/ml). The previous caries experience was compared among the groups, as was the caries increment during a 6-month period after the bacterial examination. The subjects in the S. sobrinus group had both higher caries and higher decayed teeth and surface increments than the S. mutans group. The mean decayed smooth-surface increment (delta d-surface) for the S. sobrinus group was 2.6 and was significantly higher than 0.8 for the S. mutans group. For the subjects with delta d-surface > or = 4, the mean number of S. sobrinus in the saliva was 4.29 x 10(5) CFU/ml and was significantly higher than 0.32 x 10(5) CFU/ml for the subjects without delta d-surface. There was no significant difference in the mean number of S. mutants in saliva between the subjects with and without delta d-surface. The prevalence of S. sobrinus in saliva was more closely associated with future caries activity, especially with smooth-surface caries increment, than the prevalence of S. mutants.
对338名3至5岁儿童的唾液进行了变形链球菌检测。根据分离出的优势菌种将他们分为四组：（1）变形链球菌和远缘链球菌组（变形链球菌≥10³CFU/ml且远缘链球菌≥10³CFU/ml）；（2）变形链球菌组（变形链球菌≥10³CFU/ml但远缘链球菌＜10³CFU/ml）；（3）远缘链球菌组（远缘链球菌≥10³CFU/ml但变形链球菌＜10³CFU/ml），以及（4）未检测到或几乎检测不到变形链球菌的儿童（变形链球菌＜10³CFU/ml）。比较了各组之前的龋齿经历以及细菌检测后6个月期间的龋齿增量。远缘链球菌组的受试者在龋齿和龋齿表面增量方面均高于变形链球菌组。远缘链球菌组的平均龋齿平滑面增量（δd-表面）为2.6，显著高于变形链球菌组的0.8。对于δd-表面≥4的受试者，唾液中远缘链球菌的平均数量为4.29×10⁵CFU/ml，显著高于无δd-表面受试者的0.32×10⁵CFU/ml。有和没有δd-表面的受试者唾液中变形链球菌的平均数量没有显著差异。唾液中远缘链球菌的患病率比变形链球菌的患病率与未来的龋齿活动，尤其是平滑面龋齿增量的相关性更强。
