Finley G A, MacManus B, Sampson S E, Fernandez C V, Retallick R
Department of Anaesthesia, Izaak Walton Killam Children's Hospital, Halifax, NS, Canada.
Can J Anaesth. 1993 Sep;40(9):863-5. doi: 10.1007/BF03009258.
Seizures occurred in two adolescents approximately six hours after sedation with propofol for bone marrow biopsy. Case #1 was a patient with chronic renal failure, hypertension, and anaemia. Case #2 had just been diagnosed with acute lymphocytic leukaemia. Neither child had experienced seizures before, and both recovered without neurological sequelae. Although other factors may have caused the seizures, the episodes have raised concerns about the safety of propofol for patients travelling home after out-patient surgery. Further study is required to explain the cause of this complication or, at least, to identify risk factors.
两名青少年在接受丙泊酚镇静进行骨髓活检约六小时后发生癫痫发作。病例1是一名患有慢性肾功能衰竭、高血压和贫血的患者。病例2刚被诊断为急性淋巴细胞白血病。两个孩子以前都没有癫痫发作史，且均康复，无神经后遗症。尽管其他因素可能导致了癫痫发作，但这些事件引发了人们对门诊手术后回家的患者使用丙泊酚安全性的担忧。需要进一步研究来解释这种并发症的原因，或者至少确定危险因素。
