Ulibarri C M, Yahr P
Department of Psychobiology, University of California, Irvine 92717.
Brain Res Dev Brain Res. 1993 Jul 16;74(1):14-24. doi: 10.1016/0165-3806(93)90078-o.
The sexually dimorphic area (SDA) of the gerbil hypothalamus is a set of cell groups in the medial preoptic area that is essential for masculine sexual behavior and implicated in the hormonal control of scent making and ultrasound production. The adult SDA shrinks after gonadectomy unless the gerbils receive testosterone. So does the SDA pars compacta, a small cell group in the SDA of males that is seldom seen in females. Here, development of the SDA and SDApc, and of a second, small, compact cell group, the cmSDApc, that lies caudal and medial to the SDApc, is described. Development of the SDApc and cmSDApc was studied quantitatively by assessing their incidence and volume in both sexes from birth (PND 1) to adulthood (PND 150). The volume of the entire SDA was studied from PND 45 to 150. In male gerbils, puberty begins around PND 40 and is complete by PND 90-120. The male SDA enlarged relative to the cross-sectional area of the hypothalamus as puberty began, but the female SDA did not. The SDApc was present in virtually all gerbils at birth and was the same size in both sexes. Over the next two weeks, the SDApcs of females disappeared while those of males persisted and doubled in size. Like the SDApc, the cmSDApc was larger and more common in males than in females, but it became smaller and less prevalent in both sexes during the first two weeks after birth.
沙鼠下丘脑的性二态区（SDA）是内侧视前区的一组细胞群，对雄性性行为至关重要，并参与气味产生和超声波发出的激素调控。成年沙鼠在性腺切除术后，其SDA会萎缩，除非给予睾酮。雄性SDA中的致密部（SDApc）也是如此，这是一个小细胞群，在雄性SDA中很少在雌性中见到。在此，描述了SDA和SDApc以及第二个小的致密细胞群——位于SDApc尾侧和内侧的致密部旁中央SDA（cmSDApc）的发育情况。通过评估出生（出生后第1天，PND 1）至成年（PND 150）两性中SDApc和cmSDApc的发生率和体积，对其发育进行了定量研究。从PND 45至150研究了整个SDA的体积。在雄性沙鼠中，青春期始于PND 40左右，并在PND 90 - 120时完成。随着青春期开始，雄性SDA相对于下丘脑横截面积增大，但雌性SDA没有。几乎所有沙鼠出生时都有SDApc，且两性大小相同。在接下来的两周内，雌性的SDApc消失，而雄性的则持续存在且大小翻倍。与SDApc一样，cmSDApc在雄性中比在雌性中更大且更常见，但在出生后的头两周内，两性中的cmSDApc都变得更小且更不普遍。
