Koshino Y, Nishio M, Murata T, Omori M, Murata I, Sakamoto M, Isaki K
Department of Neuropsychiatry, Fukui Medical School, Japan.
Clin Electroencephalogr. 1993 Jul;24(3):110-3. doi: 10.1177/155005949302400307.
Light drowsiness affected the P300 obtained with a standard auditory oddball paradigm. A simple two-tone discrimination paradigm was used. The frequent nontarget stimuli were 1000 Hz pure tones and the infrequent target stimuli were 2000 Hz pure tones. The subjects were required to press a button whenever infrequent target tones were presented. With light drowsiness, P300 increased in latency and decreased in amplitude, but the counts of infrequent tones remained correct nevertheless. It was concluded that electrophysiological brain function differs in the light drowsy and awake states. In studies on P300, it is essential to rule out light drowsiness to obtain valid P300 amplitudes and latencies.
轻度嗜睡影响了通过标准听觉Oddball范式获得的P300。采用了简单的双音辨别范式。频繁出现的非目标刺激是1000Hz纯音，不频繁出现的目标刺激是2000Hz纯音。要求受试者在每次出现不频繁的目标音调时按下按钮。在轻度嗜睡状态下，P300的潜伏期延长，波幅降低，但对不频繁音调的计数仍然正确。得出的结论是，轻度嗜睡状态和清醒状态下的脑电生理功能不同。在关于P300的研究中，排除轻度嗜睡以获得有效的P300波幅和潜伏期至关重要。
