He M L, Zhu K, Cao Q L
Department of Neurology, General Hospital of PLA, Beijing.
Zhonghua Nei Ke Za Zhi. 1993 Feb;32(2):94-6.
Plasma atrial natriuretic peptide (ANP) was measured with radioimmunoassay in 39 patients with acute stroke. The mean level was 144.3 +/- 8.7 pg/ml; this was significantly higher in comparison with those in normal controls (55.8 +/- 4.7 pg/ml, n = 20) and hypertension patients (87.7 +/- 8.0 pg/ml, n = 15). Serial measurement of ANP level in 6 patients showed that it was elevated on the first day of the stroke, reached to its peak on the second or third day and returned to normal after two weeks. Five patients had hyponatremia following the attack of stroke and the plasma ANP level was further elevated. It is suggested that elevated plasma ANP level might be a pathogenetic factor of the accompanying hyponatremia in stroke.
采用放射免疫分析法对39例急性脑卒中患者测定血浆心钠素（ANP）水平。其平均水平为144.3±8.7 pg/ml；与正常对照组（55.8±4.7 pg/ml，n = 20）和高血压患者（87.7±8.0 pg/ml，n = 15）相比，该水平显著更高。对6例患者的心钠素水平进行连续测定显示，在脑卒中发作首日其水平升高，在第二或第三天达到峰值，并在两周后恢复正常。5例患者在脑卒中发作后出现低钠血症，且血浆心钠素水平进一步升高。提示血浆心钠素水平升高可能是脑卒中伴发低钠血症的发病因素。
