淋巴细胞对蛋白质抗原的特异性。II. 以细胞色素c及其衍生肽作为抗原探针时T细胞激活的精细特异性。
Lymphocyte specificity to protein antigens. II. Fine specificity of T-cell activation with cytochrome c and derived peptides as antigenic probes.
作者信息
Corradin G, Chiller J M
出版信息
J Exp Med. 1979 Feb 1;149(2):436-47. doi: 10.1084/jem.149.2.436.
Abstract
Murine T-lymphocyte specificity was determined in a system of antigen driven in vitro T-cell proliferation using cytochrome c molecules from different species, their derived peptides and reconstituted hybrid proteins. It was observed that primed T cells could discriminate between peptide fragments which differed from each other at a single amino acid residue. These conclusions were substantiated by the pattern of cross-reactivity noted in the response of closely related cytochrome c proteins as well as when artificial hybrid molecules reconstituted by the covalent linkage of peptide fragments were analyzed. The pattern of specificity observed appeared to be haplotype (BDF1) dependent although similar conclusions about the fine specificity of T cells in the response to cytochrome c have been obtained in other strains but associated with different residues.
摘要
在一个利用来自不同物种的细胞色素c分子、其衍生肽和重组杂交蛋白进行抗原驱动的体外T细胞增殖系统中，确定了小鼠T淋巴细胞的特异性。据观察，致敏T细胞能够区分在单个氨基酸残基上彼此不同的肽片段。这些结论通过在密切相关的细胞色素c蛋白的反应中以及在分析通过肽片段的共价连接重建的人工杂交分子时所观察到的交叉反应模式得到了证实。所观察到的特异性模式似乎依赖于单倍型（BDF1），尽管在其他品系中也获得了关于T细胞对细胞色素c反应的精细特异性的类似结论，但与不同的残基相关。
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Lymphocyte specificity to protein antigens. II. Fine specificity of T-cell activation with cytochrome c and derived peptides as antigenic probes.淋巴细胞对蛋白质抗原的特异性。II. 以细胞色素c及其衍生肽作为抗原探针时T细胞激活的精细特异性。
J Exp Med. 1979 Feb 1;149(2):436-47. doi: 10.1084/jem.149.2.436.
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Determinant selection is a macrophage dependent immune response gene function.决定簇选择是一种巨噬细胞依赖性免疫反应基因功能。
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A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
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Reconstitution of horse heart cytochrome c: reformation of the peptide bond linking residues 65 and 66.马心脏细胞色素c的复性：连接65和66位残基的肽键的重新形成。
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On the role of heme in the formation of the structure of cytochrome c.论血红素在细胞色素c结构形成中的作用。
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Antigen-binding receptors on lymphocytes.淋巴细胞上的抗原结合受体。
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Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.豚鼠T淋巴细胞抗原识别中巨噬细胞的功能。II. 巨噬细胞在免疫反应基因控制调节中的作用。
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