Horger E O, Smythe A R
Obstet Gynecol. 1977 Mar;49(3):257-61.
In a retrospective review of 440 pregnancies occurring in women over the age of 40, increased frequencies of both perinatal and maternal complications were noted. The perinatal mortality rate of the study group was three times greater than that of the general obstetric population. There were increased incidences of both low and high birthweight infants. Neonatal morbidity was increased. Congenital abnormalities were noted in 12 infants, including 2 infants with cytogenetic abnormalities. Hypertensive disorders complicated one-third of the pregnancies. Diabetes mellitus and abruptio placentae occurred with increased frequency. Cesarean section was required in 12.2% of the deliveries.
在一项对40岁以上女性所发生的440例妊娠进行的回顾性研究中，围产期和孕产妇并发症的发生率均有所增加。研究组的围产儿死亡率是普通产科人群的三倍。低体重儿和高体重儿的发生率均有所增加。新生儿发病率也有所上升。在12例婴儿中发现了先天性异常，其中包括2例细胞遗传学异常的婴儿。三分之一的妊娠并发高血压疾病。糖尿病和胎盘早剥的发生率增加。12.2%的分娩需要进行剖宫产。
