Daniel F B, Robinson M, Olson G R, York R G, Condie L W
Ecological Monitoring Research Division, U.S. Environmental Protection Agency, Cincinnati, Ohio 45268.
Drug Chem Toxicol. 1993;16(3):277-91. doi: 10.3109/01480549309081820.
Male and female Sprague-Dawley rats received 2-chlorophenol in corn oil daily by gavage for 10 or 90 consecutive days. The 10-day study doses were 13, 64, 129 and 257 mg/kg while the 90-day subchronic study doses were 17, 50 and 150 mg/kg. In the 10-day study, hematologic and clinical chemistry, food and water consumption, absolute and relative organ weights, and histopathological findings revealed no compound or sex-related effects. In the 90-day study there were no significant gross or histopathological findings that were treatment-related in either sex. There were statistically significant differences between control and treated groups associated with hematology, clinical chemistry and organ weights; however, none of the differences were considered to be biologically meaningful.
雄性和雌性斯普拉格-道利大鼠每天通过灌胃给予玉米油中的2-氯苯酚，连续给药10天或90天。10天研究的剂量为13、64、129和257毫克/千克，而90天亚慢性研究的剂量为17、50和150毫克/千克。在10天的研究中，血液学和临床化学、食物和水的消耗、绝对和相对器官重量以及组织病理学检查结果均未显示出化合物或性别相关的影响。在90天的研究中，无论是雄性还是雌性，均未发现与治疗相关的显著大体或组织病理学变化。对照组和治疗组在血液学、临床化学和器官重量方面存在统计学上的显著差异；然而，这些差异均未被认为具有生物学意义。
