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MRL/lpr小鼠自身免疫性涎腺炎发育过程中细胞因子基因的表达。

Expressions of cytokine genes during development of autoimmune sialadenitis in MRL/lpr mice.

作者信息

Hamano H, Saito I, Haneji N, Mitsuhashi Y, Miyasaka N, Hayashi Y

机构信息

Department of Pathology, Tokushima University School of Dentistry.

出版信息

Eur J Immunol. 1993 Oct;23(10):2387-91. doi: 10.1002/eji.1830231002.

Abstract

Local cytokine gene expression in vivo was analyzed by direct analysis of RNA obtained from salivary gland tissues of MRL/lpr mice with autoimmune sialadenitis. The expression of cytokine genes were assessed by the reverse-transcriptase polymerase chain reaction, and by immunohistochemical analysis. The expression of interleukin-1(IL-1)beta and tumor necrosis factor was detected before the onset of inflammatory lesions in the salivary glands of mice of 1 or 2 months of age, and IL-6 mRNA expression was clearly detected at the time of onset of typical autoimmune sialadenitis at 3 months of age in MRL/lpr mice, and was up-regulated with advancing age. These results suggest that the overexpression of these inflammatory cytokine genes is involved in the development and progression of organ-localized autoimmunity in the salivary glands of MRL/lpr mice.

摘要

通过直接分析从患有自身免疫性涎腺炎的MRL/lpr小鼠唾液腺组织中获取的RNA,对体内局部细胞因子基因表达进行了分析。通过逆转录聚合酶链反应和免疫组织化学分析来评估细胞因子基因的表达。在1或2月龄小鼠的唾液腺炎症病变发作之前,检测到白细胞介素-1(IL-1)β和肿瘤坏死因子的表达,并且在3月龄MRL/lpr小鼠典型自身免疫性涎腺炎发作时清楚地检测到IL-6 mRNA表达,并且随着年龄增长而上调。这些结果表明,这些炎性细胞因子基因的过表达参与了MRL/lpr小鼠唾液腺中器官局部自身免疫的发生和发展。

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