Huguet E, Gené M, Corbella J, Moreno P
Laboratorio de Hemogenética Forense, Facultad de Medicina, Universidad de Barcelona, Spain.
Hum Hered. 1993 Sep-Oct;43(5):326-8. doi: 10.1159/000154153.
Allele and genotype frequencies at the HLA-DQ alpha locus were determined by the use of polymerase chain reaction (PCR) and the reverse dot blot format. 6 HLA-DQ alpha alleles and 21 genotypes were detected among the 178 unrelated individuals from Barcelona. A fair agreement was found between observed and expected numbers assuming a Hardy-Weinberg equilibrium. The Barcelona population is statistically similar to the Finnish population, but differs significantly from the Japanese, Black and Caucasoid series.
通过聚合酶链反应（PCR）和反向斑点杂交法测定了HLA-DQα基因座的等位基因和基因型频率。在来自巴塞罗那的178名无亲缘关系的个体中检测到6个HLA-DQα等位基因和21种基因型。假设处于哈迪-温伯格平衡，观察到的和预期的数量之间存在较好的一致性。巴塞罗那人群在统计学上与芬兰人群相似，但与日本、黑人及高加索人群系列有显著差异。
