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1
Characterization of a monoclonal antibody to cis-urocanic acid: detection of cis-urocanic acid in the serum of irradiated mice by immunoassay.顺式尿刊酸单克隆抗体的特性：通过免疫测定法检测受辐照小鼠血清中的顺式尿刊酸。
Immunology. 1993 Aug;79(4):667-72.
2
Differential effects of a monoclonal antibody to cis-urocanic acid on the suppression of delayed and contact hypersensitivity following ultraviolet irradiation.抗顺式尿刊酸单克隆抗体对紫外线照射后迟发型和接触性超敏反应抑制的不同作用
J Immunol. 1996 Oct 1;157(7):2891-9.
3
The role of cis-urocanic acid in UVB-induced suppression of contact hypersensitivity.顺式尿刊酸在紫外线B诱导的接触性超敏反应抑制中的作用。
Immunol Lett. 1995 Dec;48(3):181-6. doi: 10.1016/0165-2478(95)02462-X.
4
Quantification of urocanic acid isomers in murine skin during development and after irradiation with UVB light.小鼠皮肤发育过程中和紫外线B照射后尿刊酸异构体的定量分析。
Photodermatol. 1988 Aug;5(4):179-86.
5
The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration.紫外线B照射和尿刊酸异构体对树突状细胞迁移的影响。
Immunology. 1992 Nov;77(3):394-9.
6
Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid.短期紫外线照射对接触性超敏反应的抑制作用：II. 尿刊酸的作用。
Clin Exp Immunol. 1988 Apr;72(1):174-7.
7
Isomerization of urocanic acid after ultraviolet radiation is influenced by skin pigmentation.紫外线照射后尿刊酸的异构化受皮肤色素沉着的影响。
J Photochem Photobiol B. 1999 Jan;48(1):42-7. doi: 10.1016/S1011-1344(99)00007-X.
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Regulation of tumor antigen presentation by urocanic acid.尿刊酸对肿瘤抗原呈递的调节作用。
J Immunol. 1997 Jul 1;159(1):92-6.
9
The effect of histamine receptor antagonists on immunosuppression induced by the cis-isomer of urocanic acid.组胺受体拮抗剂对尿刊酸顺式异构体诱导的免疫抑制的影响。
Photodermatol Photoimmunol Photomed. 1990 Dec;7(6):243-8.
10
Urocanic acid and cutaneous antigen presentation.
J Photochem Photobiol B. 1998 Jul 10;44(2):112-6. doi: 10.1016/S1011-1344(98)00129-8.

引用本文的文献

1
Ultraviolet B suppresses immunity by inhibiting effector and memory T cells.紫外线B通过抑制效应T细胞和记忆T细胞来抑制免疫。
Am J Pathol. 2008 Apr;172(4):993-1004. doi: 10.2353/ajpath.2008.070517. Epub 2008 Feb 21.
2
Suppression of an established immune response by UVA--a critical role for mast cells.紫外线A对已建立的免疫反应的抑制作用——肥大细胞的关键作用
Photochem Photobiol. 2007 Sep-Oct;83(5):1095-100. doi: 10.1111/j.1751-1097.2007.00184.x.
3
Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor.顺式尿刊酸是一种阳光诱导的免疫抑制因子，它通过5-羟色胺2A受体激活免疫抑制作用。
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17420-5. doi: 10.1073/pnas.0603119103. Epub 2006 Nov 3.
4
UVB exposure-induced systemic modulation of Th1- and Th2-mediated immune responses.紫外线B照射诱导的Th1和Th2介导的免疫反应的全身调节。
Immunology. 1999 Jul;97(3):506-14. doi: 10.1046/j.1365-2567.1999.00801.x.
5
Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse.血红素加氧酶的诱导介导了紫外线A辐射在小鼠中的光免疫保护活性。
Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9317-21. doi: 10.1073/pnas.96.16.9317.
6
The role of urocanic acid in UVB-induced suppression of immunity to Trichinella spiralis infection in the rat.尿刊酸在紫外线B诱导的大鼠对旋毛虫感染免疫抑制中的作用。
Immunology. 1999 Feb;96(2):298-306. doi: 10.1046/j.1365-2567.1999.00698.x.
7
Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses.组胺参与紫外线B和顺式尿刊酸诱导的接触性超敏反应的全身抑制。
Immunology. 1997 Aug;91(4):601-8. doi: 10.1046/j.1365-2567.1997.00284.x.
8
The role of dendritic cells in cutaneous immunity.树突状细胞在皮肤免疫中的作用。
Arch Dermatol Res. 1996 Mar;288(3):109-21. doi: 10.1007/BF02505819.
9
Localization of DNA damage and its role in altered antigen-presenting cell function in ultraviolet-irradiated mice.紫外线照射小鼠中DNA损伤的定位及其在抗原呈递细胞功能改变中的作用。
J Exp Med. 1996 Apr 1;183(4):1491-500. doi: 10.1084/jem.183.4.1491.

本文引用的文献

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Ultraviolet-light-induced alterations in urocanic acid in vivo.紫外线诱导的体内尿刊酸改变。
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2
The use of carbodiimides in the preparation of immunizing conjugates.碳二亚胺在制备免疫结合物中的应用。
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3
Immunological unresponsiveness induced by ultraviolet radiation.紫外线辐射诱导的免疫无反应性。
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4
Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology.紫外线体内免疫抑制机制。I. 皮肤中独特光感受器的存在证据及其在光免疫学中的作用。
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The metabolism and function of urocanic acid in skin.尿刊酸在皮肤中的代谢与功能。
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6
The influence of epitope density on the immunological properties of hapten-protein conjugates. I. Characteristics of the immune response to hapten-coupled albumen with varying epitope density.表位密度对半抗原-蛋白质缀合物免疫特性的影响。I. 对半抗原密度不同的半抗原偶联白蛋白的免疫应答特征。
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7
Exposure to low-dose ultraviolet radiation suppresses delayed-type hypersensitivity to herpes simplex virus in mice.暴露于低剂量紫外线辐射会抑制小鼠对单纯疱疹病毒的迟发型超敏反应。
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8
Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid.短期紫外线照射对接触性超敏反应的抑制作用：II. 尿刊酸的作用。
Clin Exp Immunol. 1988 Apr;72(1):174-7.
9
Ultraviolet-irradiated urocanic acid suppresses delayed-type hypersensitivity to herpes simplex virus in mice.
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10
Quantification of urocanic acid isomers in murine skin during development and after irradiation with UVB light.小鼠皮肤发育过程中和紫外线B照射后尿刊酸异构体的定量分析。
Photodermatol. 1988 Aug;5(4):179-86.

顺式尿刊酸单克隆抗体的特性：通过免疫测定法检测受辐照小鼠血清中的顺式尿刊酸。

Characterization of a monoclonal antibody to cis-urocanic acid: detection of cis-urocanic acid in the serum of irradiated mice by immunoassay.

作者信息

Moodycliffe A M, Norval M, Kimber I, Simpson T J

机构信息

Department of Medical Microbiology, University of Edinburgh Medical School, U.K.

出版信息

Immunology. 1993 Aug;79(4):667-72.

PMID:8406594
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1421912/
Abstract

Cis-urocanic acid (cis-UCA), which is formed from the naturally occurring trans-isomer on ultraviolet (UV) irradiation, has been suggested as a photoreceptor for and mediator of the suppressive effects of UV irradiation on systemic immune responses. Trans-UCA is located predominantly in the stratum corneum, and the extent of isomerization to cis-UCA may be analysed by high-performance liquid chromatography (HPLC) of skin extracts. Such an analysis is not suitable for other tissues. In this study a murine monoclonal antibody to cis-UCA was prepared and tested by ELISA using UCA isomers conjugated to protein as antigens. The interaction of the antibody with structural analogues of UCA was assessed by competitive inhibition ELISA which indicated that the antibody had a high specificity for cis-UCA. Screening of sera at various times after UVB irradiation of mice by competitive inhibition ELISA using the monoclonal antibody showed that cis-UCA was present, probably in an unbound form, for at least 2 days after the exposure. Thus, cis-UCA produced in the epidermis following UVB irradiation reaches the serum a few hours later. The implications of this finding for the generation of suppressed immune responses are discussed.

摘要

顺式尿刊酸（cis-UCA）由天然存在的反式异构体经紫外线（UV）照射形成，被认为是UV照射对全身免疫反应抑制作用的光感受器和介质。反式-UCA主要位于角质层，可通过对皮肤提取物进行高效液相色谱（HPLC）分析来测定其向顺式-UCA的异构化程度。这种分析方法不适用于其他组织。在本研究中，制备了一种针对顺式-UCA的鼠单克隆抗体，并以与蛋白质偶联的UCA异构体作为抗原，通过酶联免疫吸附测定（ELISA）进行检测。通过竞争性抑制ELISA评估该抗体与UCA结构类似物的相互作用，结果表明该抗体对顺式-UCA具有高度特异性。使用该单克隆抗体通过竞争性抑制ELISA对紫外线B（UVB）照射小鼠后不同时间的血清进行筛查，结果显示顺式-UCA在暴露后至少2天内存在，可能以未结合形式存在。因此，UVB照射后表皮中产生的顺式-UCA在数小时后到达血清。本文讨论了这一发现对免疫反应抑制产生的影响。