Sharma A, Gathwala G
Department of Pediatrics, Medical College, Rohtak, Haryana.
Indian Pediatr. 1993 Jan;30(1):47-50.
Sixty five blood culture positive cases of S. typhi were studied for clinical profile. A total of 64.6% were multidrug resistant and 35.4% were chloramphenicol sensitive. In patients with multidrug resistant S. typhi the age was higher (p < 0.01), and incidence of complications such as shock (35.7%), encephalopathy (42.9%), myocarditis (14.3%) and gastric hemorrhage (4.7%) were more frequent, compared to chloramphenicol sensitive group. Cases with multidrug resistant S. typhi (MDRST) were treated with oral ciprofloxacin; the period of defervescence of fever was significantly less (p < 0.05) compared to the chloramphenicol group. Our study suggests the use of ciprofloxacin in the treatment of MDRST without any side effects.
对65例血培养伤寒沙门氏菌阳性病例的临床特征进行了研究。共有64.6%为多重耐药，35.4%对氯霉素敏感。与氯霉素敏感组相比，多重耐药伤寒沙门氏菌患者年龄较大（p<0.01），休克（35.7%）、脑病（42.9%）、心肌炎（14.3%）和胃出血（4.7%）等并发症的发生率更高。多重耐药伤寒沙门氏菌（MDRST）病例采用口服环丙沙星治疗；与氯霉素组相比，发热退热期明显缩短（p<0.05）。我们的研究表明，使用环丙沙星治疗MDRST没有任何副作用。
