Singh C P, Singh N, Brar G K, Lal G, Kumar H
Department of Medicine, GGS Medical College and Hospital, Faridkot.
J Indian Med Assoc. 1993 Jun;91(6):156-7.
Twenty-five out of 55 patients of enteric fever were documented as multidrug resistant enteric fever cases. In the resistant cases the drug sensitivity of salmonella species in vitro were mainly augmentin, ceftriaxone, aminoglycosides, ciprofloxacin and norfloxacin. Sixteen patients were treated with ciprofloxacin and 9 were treated with norfloxacin for 14 days. Fever touched normal in 62.5% cases with ciprofloxacin and in 33.3% cases with norfloxacin by the 7th day. It became normal in 88% with ciprofloxacin and in 66% with norfloxacin by the 10th day and it became normal in 100% cases in each group by the 14th day. The newer 4-quinolones can be recommended in multidrug resistant enteric fever in adults.
55例伤寒患者中有25例被记录为多重耐药伤寒病例。在耐药病例中，沙门氏菌体外药敏主要为阿莫西林克拉维酸钾、头孢曲松、氨基糖苷类、环丙沙星和诺氟沙星。16例患者接受环丙沙星治疗，9例患者接受诺氟沙星治疗14天。到第7天，环丙沙星治疗组62.5%的患者体温恢复正常，诺氟沙星治疗组为33.3%。到第10天，环丙沙星治疗组88%的患者体温恢复正常，诺氟沙星治疗组为66%。到第14天，两组患者体温均100%恢复正常。新型4-喹诺酮类药物可推荐用于成人多重耐药伤寒的治疗。
