Friedman H S, Abramowitz I, Nguyen T, Babb B, Stern M, Farrer S M, Tricomi V
Am J Med. 1987 Aug;83(2):261-4. doi: 10.1016/0002-9343(87)90695-4.
High concentrations of digoxin-like immunoreactive substance (DLIS) have been identified in amniotic fluid and in blood during pregnancy. In this study, urine from healthy women was analyzed for DLIS during pregnancy and following delivery, and levels were related to various clinical and urinary findings. Urinary DLIS increased progressively during pregnancy, having a linear relation to gestational week (DLIS = 0.032 week + 0.46, Syx = 0.52, r = 0.46, p less than 0.01), and fell to nonpregnant values during the first postpartum day. The urinary DLIS level correlated with urinary creatinine (r = 0.50, p less than 0.01) and urinary calcium (r = 0.56, p less than 0.01) levels. When adjusted for the gestational week, the urinary DLIS level also correlated with urinary potassium (r = 0.48, p less than 0.01), creatinine (r = 0.55, p less than 0.01), and magnesium (r = 0.55, p less than 0.01) levels. After adjustment for the urinary creatinine level, only the relation of urinary DLIS and urinary calcium levels remained significant (r = 0.44, p less than 0.05). The urinary DLIS level was not found to be related to systemic blood pressure. The ratios of sodium to potassium (r = -0.43, p less than 0.05) and calcium to magnesium (r = 0.37, p less than 0.05) were also related to gestational week but were independent of the urinary DLIS level. Thus, urinary DLIS increases progressively during pregnancy and falls to nonpregnant values on the first postpartum day, the urinary DLIS level can be related to urinary creatinine, urinary potassium, and urinary magnesium levels, and when adjusted for the urinary creatinine level, the urinary calcium level relates independently to the urinary DLIS level.
孕期羊水中及血液中已检测出高浓度的地高辛样免疫反应物质（DLIS）。本研究分析了健康女性孕期及产后尿液中的DLIS，并将其水平与各种临床及尿液检查结果相关联。孕期尿中DLIS水平逐渐升高，与孕周呈线性关系（DLIS = 0.032孕周 + 0.46，Syx = 0.52，r = 0.46，p＜0.01），产后第一天降至非孕期水平。尿中DLIS水平与尿肌酐（r = 0.50，p＜0.01）及尿钙（r = 0.56，p＜0.01）水平相关。校正孕周后，尿中DLIS水平还与尿钾（r = 0.48，p＜0.01）、肌酐（r = 0.55，p＜0.01）及镁（r = 0.55，p＜0.01）水平相关。校正尿肌酐水平后，仅尿中DLIS与尿钙水平的关系仍具有显著性（r = 0.44，p＜0.05）。未发现尿中DLIS水平与体循环血压相关。钠钾比值（r = -0.43，p＜0.05）及钙镁比值（r = 0.37，p＜0.05）也与孕周相关，但与尿中DLIS水平无关。因此，孕期尿中DLIS水平逐渐升高，产后第一天降至非孕期水平，尿中DLIS水平可与尿肌酐、尿钾及尿镁水平相关，校正尿肌酐水平后，尿钙水平独立与尿中DLIS水平相关。
