Clerico A, Giampietro O, Gregori G, Del Chicca M G, Bertoli S, Miccoli R, Navalesi R
C.N.R. Institute of Clinical Physiology, University of Pisa, Italy.
Clin Chem. 1988 Mar;34(3):554-6.
To verify whether there is a variation in the 24-h urinary excretion of digoxin-like immunoreactivity (DLIS) in humans, we studied 18 normal adults, who collected their urines for 24-h in several portions. We then measured DLIS (by means of a sensitive RIA method), creatinine, sodium, and potassium concentrations in the urine samples. The mean urinary excretion rate for DLIS in the complete 24-h collection was 84.8 (SD 31.3) pg/min. The mean DLIS urinary excretion rate calculated for overnight collections was significantly lower than those of afternoon collections (P less than 0.01) and the 24-h collection (P less than 0.05). Significant positive correlations were found between urinary DLIS and excretion rates for creatinine (r = 0.347, P = 0.0016), Na+ (r = 0.232, P = 0.038), and K+ (r = 0.323, P = 0.003), respectively. Our data suggest that urinary excretion of DLIS is higher during "active" hours of the day, especially in the afternoon, than at rest, during the night.
为了验证人体地高辛样免疫反应物（DLIS）的24小时尿排泄量是否存在变化，我们研究了18名正常成年人，他们分几次收集24小时尿液。然后我们测量了尿样中DLIS（采用灵敏的放射免疫分析法）、肌酐、钠和钾的浓度。24小时完整收集尿液中DLIS的平均排泄率为84.8（标准差31.3）皮克/分钟。夜间收集尿液计算出的DLIS平均排泄率显著低于下午收集的排泄率（P<0.01）和24小时收集的排泄率（P<0.05）。尿中DLIS与肌酐排泄率（r = 0.347，P = 0.0016）、Na+排泄率（r = 0.232，P = 0.038）和K+排泄率（r = 0.323，P = 0.003）之间分别存在显著正相关。我们的数据表明，一天中“活跃”时段，尤其是下午，DLIS的尿排泄量高于夜间休息时。
