组织蛋白酶B在人肺腺癌中表达的免疫组织化学分析：在癌症进展中的作用
Immunohistochemical analysis of cathepsin B expression in human lung adenocarcinoma: the role in cancer progression.
作者信息
Ozeki Y, Takishima K, Takagi K, Aida S, Tamai S, Mamiya G, Ogata T
机构信息
Department of Biochemistry, National Defense Medical College, Saitama.
出版信息
Jpn J Cancer Res. 1993 Sep;84(9):972-5. doi: 10.1111/j.1349-7006.1993.tb00187.x.
Production of cathepsin B by tumor cells has been linked to metastatic potential in several experimental models. Sections of 95 primary lung adenocarcinomas were examined for expression of cathepsin B using a standard avidin-biotin immunohistochemical technique. Staining for cathepsin B was observed in 22.1% of all cases and 28.0% of those of the Clara cell type. In Clara cell adenocarcinomas, cathepsin B expression correlated with positive lymph node status, presence of distant metastases, and poor prognosis (P < 0.05). However, no correlation with clinical outcome was observed in other cell types. Our data suggest that cathepsin B may be involved in invasion and metastasis in Clara cell lung adenocarcinoma.
在多个实验模型中，肿瘤细胞组织蛋白酶B的产生与转移潜能相关。采用标准抗生物素蛋白-生物素免疫组化技术，检测了95例原发性肺腺癌切片中组织蛋白酶B的表达。在所有病例中，22.1%观察到组织蛋白酶B染色阳性，在 Clara 细胞型病例中这一比例为28.0%。在 Clara 细胞腺癌中，组织蛋白酶B表达与阳性淋巴结状态、远处转移的存在及预后不良相关（P < 0.05）。然而，在其他细胞类型中未观察到与临床结果的相关性。我们的数据表明，组织蛋白酶B可能参与 Clara 细胞型肺腺癌的侵袭和转移。
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