Pickles J O
Department of Physiology and Pharmacology, University of Queensland, Australia.
Hear Res. 1993 Aug;68(2):159-72. doi: 10.1016/0378-5955(93)90120-p.
The stereociliar bundle on acousticolateral hair cells was modelled as a series of stiff rods (stereocilia), and springs (stereociliary links and rootlets). Predictions were made for the coupling of stimulus-induced deflections between the stereocilia on the hair bundle, and for the stretches of the different classes of link. Comparison of the results with the measured mechanical properties of hair bundles suggests that in the bullfrog sacculus the stiffness of a side link and a tip link are related to the rootlet's contribution to the stiffness of a stereocilium to deflection in approximately the ratio > or = 400:100:1. The results show that stretch of the tip links is closely related to the deflection of the hair bundle over a wide range of model parameters, while the stretch of the side links is more variable, and in some types of bundle the mean stretch of the side links may be zero or negative. The results are in accordance with the view that the tip links are in an appropriate position to detect the deflections, while the main role for the side links may be to couple the deflections between the stereocilia. The mechanical consequences of bundles of different configurations, as seen in different hair cell types, are investigated.
将听外侧毛细胞上的静纤毛束建模为一系列刚性杆（静纤毛）和弹簧（静纤毛连接和小根）。对毛束上静纤毛之间刺激诱导的偏转耦合以及不同类型连接的拉伸进行了预测。将结果与毛束测量的力学特性进行比较表明，在牛蛙球囊中，侧向连接和顶端连接的刚度与小根对静纤毛在偏转时刚度的贡献之比约为≥400:100:1。结果表明，在广泛的模型参数范围内，顶端连接的拉伸与毛束的偏转密切相关，而侧向连接的拉伸变化更大，并且在某些类型的毛束中，侧向连接的平均拉伸可能为零或为负。这些结果与以下观点一致：顶端连接处于检测偏转的合适位置，而侧向连接的主要作用可能是在静纤毛之间耦合偏转。研究了不同毛细胞类型中不同构型毛束的力学后果。
