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一种静纤毛顶端连接丝拉伸模型。

A model of stereociliary tip-link stretches.

作者信息

Geisler C D

机构信息

Department of Neurophysiology, University of Wisconsin-Madison 53706.

出版信息

Hear Res. 1993 Feb;65(1-2):79-82. doi: 10.1016/0378-5955(93)90203-d.

DOI:10.1016/0378-5955(93)90203-d
PMID:8458761
Abstract

A model of the tip-link stretches produced by angular deflections of the stereocilia of vertebrate acoustico-lateralis hair cells is presented. It is shown that tip-link stretch in the model is proportional to the angle of stereociliary deflection. By contrast, the stretch of a horizontal (e.g., row-to-row) link is proportional to the square of the angle of stereociliary deflection. Possible roles of these stretches in sensory transduction are discussed.

摘要

提出了一种由脊椎动物听觉侧线毛细胞静纤毛角向偏转产生的纤毛顶端连接拉伸模型。结果表明,模型中的纤毛顶端连接拉伸与静纤毛偏转角成正比。相比之下,水平(例如,排与排之间)连接的拉伸与静纤毛偏转角的平方成正比。讨论了这些拉伸在感觉转导中的可能作用。

相似文献

1
A model of stereociliary tip-link stretches.一种静纤毛顶端连接丝拉伸模型。
Hear Res. 1993 Feb;65(1-2):79-82. doi: 10.1016/0378-5955(93)90203-d.
2
A model for the mechanics of the stereociliar bundle on acousticolateral hair cells.一种关于听外侧毛细胞静纤毛束力学原理的模型。
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Mechanotransduction in vertebrate hair cells: structure and function of the stereociliary bundle.脊椎动物毛细胞中的机械转导:静纤毛束的结构与功能
Am J Physiol. 1995 Jan;268(1 Pt 1):C1-13. doi: 10.1152/ajpcell.1995.268.1.C1.
4
Row-to-row horizontal links may be associated with the transduction channels of hair cells.行与行之间的水平连接可能与毛细胞的转导通道有关。
ORL J Otorhinolaryngol Relat Spec. 1996 Jan-Feb;58(1):1-3. doi: 10.1159/000276785.
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Kinematic analysis of shear displacement as a means for operating mechanotransduction channels in the contact region between adjacent stereocilia of mammalian cochlear hair cells.将剪切位移作为一种操作哺乳动物耳蜗毛细胞相邻静纤毛接触区域机械转导通道的手段进行运动学分析。
Proc Biol Sci. 1997 Jan 22;264(1378):45-51. doi: 10.1098/rspb.1997.0007.
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The tip link's role in asymmetric stereocilia motion of chick cochlear hair cells.纤毛顶端连接在雏鸡耳蜗毛细胞不对称静纤毛运动中的作用。
Hear Res. 1999 Jan;127(1-2):14-21. doi: 10.1016/s0378-5955(98)00167-1.
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Imaging hair cell transduction at the speed of sound: dynamic behavior of mammalian stereocilia.以声速成像毛细胞转导:哺乳动物静纤毛的动态行为
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Mechanoelectrical transduction by hair cells.毛细胞的机械电转导
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A nonlinear model for transduction in hair cells.一种用于毛细胞转导的非线性模型。
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Stereocilia mediate transduction in vertebrate hair cells (auditory system/cilium/vestibular system).静纤毛介导脊椎动物毛细胞(听觉系统/纤毛/前庭系统)中的转导过程。
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1506-9. doi: 10.1073/pnas.76.3.1506.

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LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel.LHFPL5 是从纤毛顶端连接到毛细胞机械换能通道的力传输的关键元素。
Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2318270121. doi: 10.1073/pnas.2318270121. Epub 2024 Jan 9.
2
Dimensions of a Living Cochlear Hair Bundle.活体内耳蜗毛细胞束的尺寸
Front Cell Dev Biol. 2021 Nov 25;9:742529. doi: 10.3389/fcell.2021.742529. eCollection 2021.
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The physiology of mechanoelectrical transduction channels in hearing.听觉中机械电转导通道的生理学
Physiol Rev. 2014 Jul;94(3):951-86. doi: 10.1152/physrev.00038.2013.
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Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells.尖端链接的分子重塑是听觉毛细胞机械感觉再生的基础。
PLoS Biol. 2013;11(6):e1001583. doi: 10.1371/journal.pbio.1001583. Epub 2013 Jun 11.
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Sliding adhesion confers coherent motion to hair cell stereocilia and parallel gating to transduction channels.滑动黏附赋予毛细胞静纤毛连贯运动,并使转导通道平行门控。
J Neurosci. 2010 Jul 7;30(27):9051-63. doi: 10.1523/JNEUROSCI.4864-09.2010.
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Fast adaptation and Ca2+ sensitivity of the mechanotransducer require myosin-XVa in inner but not outer cochlear hair cells.机械转导器的快速适应性和钙离子敏感性在内侧而非外侧耳蜗毛细胞中需要肌球蛋白XV a。
J Neurosci. 2009 Apr 1;29(13):4023-34. doi: 10.1523/JNEUROSCI.4566-08.2009.
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Mechano-electrical transduction: new insights into old ideas.机械电转导:对旧观念的新见解
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Mechanical properties and consequences of stereocilia and extracellular links in vestibular hair bundles.前庭毛束中静纤毛和细胞外连接的力学特性及影响
Biophys J. 2006 Apr 15;90(8):2786-95. doi: 10.1529/biophysj.105.066027. Epub 2006 Jan 20.
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Kinematic analysis of shear displacement as a means for operating mechanotransduction channels in the contact region between adjacent stereocilia of mammalian cochlear hair cells.将剪切位移作为一种操作哺乳动物耳蜗毛细胞相邻静纤毛接触区域机械转导通道的手段进行运动学分析。
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