Newbold C J, Wallace R J, Walker N D
Rowett Research Institute, Bucksburn, Aberdeen, UK.
J Appl Bacteriol. 1993 Aug;75(2):129-34. doi: 10.1111/j.1365-2672.1993.tb02757.x.
The Gram-negative rumen bacteria Fibrobacter succinogenes S85, Prevotella ruminicola M384 and Veillonella parvula L59 were grown in media containing successively increasing concentrations of the ionophores, monensin and tetronasin. All three species became more resistant to the ionophore with which they were grown. Increased resistance to one ionophore caused increased resistance to the other, and cross-resistance to another ionophore--lasalocid--and an antibiotic--avoparcin. Recovery of tetronasin-resistant bacteria from the rumen of monensin-fed sheep increased and vice versa, indicating that similar cross-resistance occurred in vivo.
革兰氏阴性瘤胃细菌琥珀酸纤维杆菌S85、瘤胃普氏菌M384和小韦荣球菌L59在含有浓度依次递增的离子载体莫能菌素和四霉素的培养基中培养。这三个菌种对其生长所用的离子载体都产生了更强的抗性。对一种离子载体抗性的增强导致对另一种离子载体抗性的增强，以及对另一种离子载体——拉沙里菌素——和一种抗生素——阿伏帕星产生交叉抗性。从喂食莫能菌素的绵羊瘤胃中回收的耐四霉素细菌增加，反之亦然，这表明在体内也发生了类似的交叉抗性。
