Zahn C M, Hankins G D, Yeomans E R
Department of Obstetrics and Gynecology, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas 78236-5300.
J Reprod Med. 1993 Aug;38(8):599-602.
Hydramnios complicates up to 1.6% of pregnancies, with major fetal malformations found in an average of 20% of patients with hydramnios. Chromosomal abnormalities, although associated with some conditions in which hydramnios is present, have not been reported to complicate a significant percentage of hydramnios cases. Data from 45 patients admitted during the period January 1, 1985-May 31, 1990, were analyzed. All patients had hydramnios sufficiently severe to merit hospitalization for diagnosis and/or treatment. Amniocentesis was performed at the discretion of the attending physician and not under a specific protocol. The incidence of major fetal structural malformations was 36%. Of patients in whom amniocentesis was performed, 22% were found to have karyotypic abnormalities, none of which was specifically suspected prior to the amniocenteses. Neither the estimated gestational age nor the assessment of the amount of amniotic fluid differed between those with karyotypic abnormalities and those with normal chromosome complements. This information suggests that both advanced ultrasound studies and amniocentesis are beneficial in the evaluation of hydramnios.
羊水过多在高达1.6%的妊娠中出现并发症，平均20%的羊水过多患者存在严重胎儿畸形。染色体异常虽然与一些伴有羊水过多的情况有关，但尚未报道其在显著比例的羊水过多病例中导致并发症。对1985年1月1日至1990年5月31日期间收治的45例患者的数据进行了分析。所有患者的羊水过多严重到足以因诊断和/或治疗而住院。羊膜穿刺术由主治医生酌情进行，并非按照特定方案操作。严重胎儿结构畸形的发生率为36%。在进行羊膜穿刺术的患者中，22%被发现有核型异常，在羊膜穿刺术前均未被特别怀疑。有核型异常者与染色体组正常者之间的估计孕周和羊水评估量均无差异。这些信息表明，先进的超声检查和羊膜穿刺术在羊水过多的评估中均有益处。
