Grischke E M, Schmidt W
Geburtshilfe Frauenheilkd. 1987 Jun;47(6):367-74. doi: 10.1055/s-2008-1036138.
95 patients were prospectively examined from 1982-1986 in a diagnostic programme. These patients showed a clinically and ultrasonically established acute hydramnios during the second half of their pregnancy period. Possible important causes of an acute hydramnios can be confirmed or excluded via on-target sonography; at the same time, a diabetic condition must be excluded and the amniotic fluid must be examined to exclude acute viral or specific bacterial infections. In 8 cases (8%) we found that the mother had diabetes mellitus requiring insulin, the hydramnios being the main pointer towards the metabolic disturbance. Gestation diabetes was confirmed in 23 patients (25%) on the basis of the polyhydramnios. Chromosomal anomalies were seen in 12 eucyeses (13%) and in 2 polycyeses. In 8 pregnancies (8%) we found a pattern of non-immunological hydrops fetalis with pleural effusions and ascites. In three patients (3%) there was an immunological hydrops fetalis with polyserositis within an Rh incompatibility pattern. Severe foetal malformations associated with a normal karyotype were sonographically found in 12 pregnancies--encyeses and twins--(12%). Cardiac disturbances (tachyarrhythmia) resulted in polyhydramnios in 8 cases of eucyesis (8%). Finally, 10 cases only remained unclarified (11%). 14 cases (15%) had twin pregnancy. In this connection we observed on the average an earlier onset of acute hydramnios (27 weeks) compared with the eucyeses (on the average during the 30th week). Timely and adequate treatment may become possible if we know the aetiology of the acute hydramnios, especially in cases of diabetes mellitus and gestation diabetes, as well as in certain foetal malfunctions, such as e.g. pleural effusions and generalised hydrops fetalis and disturbances of cardiac rhythm.(ABSTRACT TRUNCATED AT 250 WORDS)
1982年至1986年期间,对95名患者进行了前瞻性诊断检查。这些患者在妊娠后半期临床和超声检查确诊为急性羊水过多。通过针对性超声检查可确认或排除急性羊水过多的可能重要原因;同时,必须排除糖尿病情况,并检查羊水以排除急性病毒或特定细菌感染。8例(8%)患者中,我们发现母亲患有需胰岛素治疗的糖尿病,羊水过多是代谢紊乱的主要指征。23例(25%)患者基于羊水过多确诊为妊娠期糖尿病。12例单胎妊娠(13%)和2例多胎妊娠中发现染色体异常。8例妊娠(8%)中,我们发现了非免疫性胎儿水肿伴胸腔积液和腹水的情况。3例(3%)患者出现了Rh血型不合模式下伴有多浆膜炎的免疫性胎儿水肿。超声检查发现12例妊娠(单胎和双胎)(12%)存在与正常核型相关的严重胎儿畸形。8例单胎妊娠(8%)因心脏紊乱(快速心律失常)导致羊水过多。最后,仅10例原因不明(11%)。14例(15%)为双胎妊娠。在此方面,我们观察到与单胎妊娠相比(平均在第30周),双胎妊娠急性羊水过多的发病时间更早(平均27周)。如果我们了解急性羊水过多的病因,特别是在糖尿病和妊娠期糖尿病病例以及某些胎儿功能异常(如胸腔积液、全身性胎儿水肿和心律紊乱)的情况下,及时且充分的治疗才有可能实现。(摘要截选至250字)