Menashe Y, Ben-Baruch G, Greenspoon J S, Carp H J, Rosen D J, Mashiach S, Many A
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
J Reprod Med. 1993 Aug;38(8):625-9.
Four women with the antiphospholipid syndrome associated with lupus anticoagulant and a poor obstetric history were treated with a combination of glucocorticosteroids, anticoagulants and platelet inhibitor therapy. All patients had at least one previous miscarriage while receiving prednisone and low-dose aspirin. The treatment regimen included: aspirin, dipyridamole, prednisone, and warfarin or heparin. This treatment resulted in a successful pregnancy outcome in all cases, without preeclampsia or recurrence of thrombosis. One patient developed a vertebral compression fracture while receiving heparin and prednisone. Two pregnancies required cesarean delivery for fetal distress at 32 and 34 weeks. All four infant birth weights were appropriate for the gestational age. This regimen may be a therapeutic option for patients with the antiphospholipid antibody syndrome, especially if they have failed other commonly used treatments.
四名患有与狼疮抗凝物相关的抗磷脂综合征且有不良产科病史的女性接受了糖皮质激素、抗凝剂和血小板抑制剂联合治疗。所有患者在接受泼尼松和低剂量阿司匹林治疗期间至少有过一次流产。治疗方案包括：阿司匹林、双嘧达莫、泼尼松以及华法林或肝素。这种治疗使所有病例都获得了成功的妊娠结局，未出现先兆子痫或血栓复发。一名患者在接受肝素和泼尼松治疗时发生了椎体压缩性骨折。两次妊娠因胎儿窘迫分别在32周和34周时进行了剖宫产。所有四名婴儿的出生体重均与孕周相符。该方案可能是抗磷脂抗体综合征患者的一种治疗选择，尤其是在他们对其他常用治疗方法无效的情况下。
