Pelletier J P, Martel-Pelletier J
Centre de recherche, Hôpital Notre-Dame, Montreal, PQ, Canada.
J Rheumatol Suppl. 1993 Aug;39:19-24.
Osteoarthritis (OA) is characterized by several pathological events, including a progressive erosion of the articular cartilage (particularly the weight bearing areas of the joint), synovial inflammation, which may contribute to disease progression, and changes in the lubricating properties of the synovial fluid (SF). We discuss the pathological features that may be involved in the progression of OA, and the implications of the restoration of the viscoelastic properties of the SF (viscosupplementation) as a therapeutic modality for the treatment of OA.
骨关节炎（OA）具有多种病理特征，包括关节软骨（尤其是关节的负重区域）的渐进性侵蚀、可能导致疾病进展的滑膜炎症以及滑液（SF）润滑特性的改变。我们讨论了可能参与OA进展的病理特征，以及恢复SF粘弹性特性（粘弹性补充疗法）作为OA治疗方式的意义。
