Wright K E, Maurer S G, Di Cesare P E
Musculoskeletal Research Center, Department of Orthopaedic Surgery, Hospital for Joint Diseases Orthopaedic Institute, New York, New York, USA.
Am J Orthop (Belle Mead NJ). 2000 Feb;29(2):80-8; discussion 88-9.
Viscosupplementation therapy can restore the elastic and viscous properties of synovial fluid and thus recreate the intra-articular joint homeostasis that is disrupted in the degenerative joint. Hyaluronan (hyaluronic acid) products have been developed and used for viscosupplementation therapy in osteoarthritis. Viscosupplementation treatments using these products are well tolerated. Because viscosupplementation therapy is based on the concept of replenishing a normal physiological component of synovial fluid and cartilaginous tissue, exogenous administration of hyaluronic acid has the potential to have few side effects or local or systemic reactions. Viscosupplementation represents an alternative treatment for patients with osteoarthritis in which oral medications and/or surgery are not options or are ineffective.
关节腔注射补充疗法可以恢复滑液的弹性和粘性特性，从而重建在退行性关节中被破坏的关节内稳态。透明质酸产品已被开发并用于骨关节炎的关节腔注射补充疗法。使用这些产品进行的关节腔注射补充治疗耐受性良好。由于关节腔注射补充疗法基于补充滑液和软骨组织正常生理成分的概念，外源性给予透明质酸可能具有很少的副作用或局部或全身反应。对于骨关节炎患者，当口服药物和/或手术不是选择或无效时，关节腔注射补充疗法是一种替代治疗方法。
