携带MN血型抗原的血型糖蛋白的灵长类动物基因。
Primate genes for glycophorins carrying MN blood group antigens.
作者信息
Kudo S, Onda M, Rearden A, Fukuda M
机构信息
La Jolla Cancer Research Foundation, Cancer Research Center, CA 92037.
出版信息
J Med Primatol. 1993 Jan;22(1):7-12.
Glycophorin A, B, and E genes were derived from a common ancestral gene and this gene family appeared during primate evolution, probably between orangutan and gorilla divergences. Based on the study of genomic structures of these human glycophorins and the genetic and immunological study of primate glycophorins, we hypothesize that chimpanzee and gorilla glycophorin B could possess a longer extracellular region and carry a stronger N blood group antigenicity compared with that of the human.
血型糖蛋白A、B和E基因源自一个共同的祖先基因，这个基因家族出现在灵长类动物进化过程中，可能在猩猩和大猩猩分化之间。基于对这些人类血型糖蛋白基因组结构的研究以及对灵长类血型糖蛋白的遗传和免疫学研究，我们推测，与人类相比，黑猩猩和大猩猩的血型糖蛋白B可能具有更长的细胞外区域，并携带更强的N血型抗原性。
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