Socha W W, Moor-Jankowski J
Laboratory for Experimental Medicine and Surgery in Primates (LEMSIP), New York University School of Medicine, New York.
J Med Primatol. 1993 Jan;22(1):3-6.
Poly- and monoclonal anti-M and anti-N reagents detect on the red cells of anthropoid apes the M and/or N antigens which are similar to, but not identical with human M and N. A series of V-A-B-D specificities, closely related to the M-N system, are recognized on ape red blood cells by chimpanzee immune sera. To account for the distributions of the M-N--V-A-B-D types in man and in various apes, a genetic model is proposed that assumes the existence of two independent pairs of alleles: M/m, and N/n. In the processes of speciation, some of the alleles were lost or replaced by multiple mutations, resulting in chimpanzee in a series of codominant alleles responsible for as many as 16 M-N--V-A-B-D phenotypes.
多克隆和单克隆抗-M及抗-N试剂可在类人猿的红细胞上检测到与人类M和N相似但不完全相同的M和/或N抗原。黑猩猩免疫血清可在猿类红细胞上识别出一系列与M-N系统密切相关的V-A-B-D特异性。为了解释人类和各种猿类中M-N--V-A-B-D类型的分布情况，提出了一种遗传模型，该模型假定存在两对独立的等位基因：M/m和N/n。在物种形成过程中，一些等位基因丢失或被多次突变取代，导致黑猩猩出现了一系列共显性等位基因，这些等位基因可产生多达16种M-N--V-A-B-D表型。
