MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline).
出版信息
IARC Monogr Eval Carcinog Risks Hum. 1993;56:211-28.
Abstract
摘要
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Gut Microbial Transformation of the Dietary Imidazoquinoxaline Mutagen MelQx Reduces Its Cytotoxic and Mutagenic Potency.膳食中咪唑喹喔啉类诱变剂 MelQx 的肠道微生物转化降低了其细胞毒性和致突变性。
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Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo [4,5-f ]quinoxaline (MeIQx) in rats.在大鼠中，经胎盘和母乳接触2-氨基-3,8-二甲基咪唑[4,5-f]喹喔啉（MeIQx）会诱导DNA加合物形成并使8-羟基-2'-脱氧鸟苷增加，但子代肝脏中未出现癌前病变。
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Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine.低剂量的2-氨基-3,8-二甲基咪唑并[4,5-f]喹喔啉或N-亚硝基二乙胺在大鼠肝脏中致癌性缺乏剂量-反应关系。
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