Fleischer K, Fiedler R
Res Exp Med (Berl). 1977 Jan 28;169(3):253-9. doi: 10.1007/BF01852063.
After a 3- and 8 day administration of cyclophosphamide to rats an approximately dose-dependent decrease in the pancreatic secretion of protein and enzyme activities was demonstrable in vivo under exogenous stimulation with secretin and pancreozymin. The volume of secretion and the electrolyte outputs were found to be slightly lowered. An impairment in enzyme synthesis resulting from cyclophosphamide administration is suggested as the major cause of the observed changes in secretion.
在给大鼠连续3天和8天施用环磷酰胺后，在促胰液素和胰酶泌素的外源性刺激下，可在体内证实胰腺蛋白质分泌和酶活性呈近似剂量依赖性降低。发现分泌量和电解质排出量略有降低。环磷酰胺给药导致的酶合成受损被认为是观察到的分泌变化的主要原因。
