Antelman S M, Caggiula A R
Science. 1977 Feb 18;195(4279):646-53. doi: 10.1126/science.841304.
The proposed hypothesis is directed toward explaining a number of disparate findings in terms of a stress-related interaction between the NE- and DA-containing systems in the brain. The deleterious behavioral effects of decreased DA activity, for example, may be counterbalanced by a similar decrease occurring in NE activity, such compensation being most likely to occur under conditions of stress. This hypothesis may have application to the understanding of neurological and mental disorders such as Parkinson's disease and schizophrenia.
所提出的假说旨在从大脑中含去甲肾上腺素（NE）和多巴胺（DA）的系统之间与应激相关的相互作用方面，解释一些不同的研究结果。例如，DA活性降低的有害行为效应可能会被NE活性的类似降低所抵消，这种补偿最有可能在应激条件下发生。这一假说可能有助于理解诸如帕金森病和精神分裂症等神经和精神疾病。
