Positron emission tomography and histopathology in Creutzfeldt-Jakob disease.
作者信息
Goldman S, Laird A, Flament-Durand J, Luxen A, Bidaut L M, Stanus E, Hildebrand J, Przedborski S
机构信息
PET/Biomedical Cyclotron Unit, ULB-Hôpital Erasme, Belgium.
出版信息
Neurology. 1993 Sep;43(9):1828-30. doi: 10.1212/wnl.43.9.1828.
PMID:8414042
Abstract
We studied a 62-year-old man with Creutzfeldt-Jakob disease (CJD), using positron emission tomography (PET) and (18F)-2-fluoro-2-deoxy-D-glucose (FDG). Glucose metabolism was heterogeneously decreased throughout the brain. At autopsy, regional distributions of spongiosis, astrogliosis, and neuronal loss correlated with premortem regional metabolic deficits. These results suggest that PET with FDG may provide metabolic regional markers for CJD neuropathology.
摘要
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