克雅氏病中的正电子发射断层扫描与组织病理学

Positron emission tomography and histopathology in Creutzfeldt-Jakob disease.

作者信息

Goldman S, Laird A, Flament-Durand J, Luxen A, Bidaut L M, Stanus E, Hildebrand J, Przedborski S

机构信息

PET/Biomedical Cyclotron Unit, ULB-Hôpital Erasme, Belgium.

出版信息

Neurology. 1993 Sep;43(9):1828-30. doi: 10.1212/wnl.43.9.1828.

DOI:10.1212/wnl.43.9.1828

PMID:8414042

Abstract

We studied a 62-year-old man with Creutzfeldt-Jakob disease (CJD), using positron emission tomography (PET) and (18F)-2-fluoro-2-deoxy-D-glucose (FDG). Glucose metabolism was heterogeneously decreased throughout the brain. At autopsy, regional distributions of spongiosis, astrogliosis, and neuronal loss correlated with premortem regional metabolic deficits. These results suggest that PET with FDG may provide metabolic regional markers for CJD neuropathology.

摘要

我们使用正电子发射断层扫描（PET）和（18F）-2-氟-2-脱氧-D-葡萄糖（FDG）对一名62岁的克雅氏病（CJD）男性患者进行了研究。全脑葡萄糖代谢呈不均匀降低。尸检时，海绵状变性、星形胶质细胞增生和神经元丢失的区域分布与生前区域代谢缺陷相关。这些结果表明，FDG-PET可能为CJD神经病理学提供代谢区域标志物。