Jenkins T, Lane A B, Kromberg J G
S Afr Med J. 1977 Jan 22;51(4):95-8.
Tay-Sachs disease is potentially preventable in Ashkenazi Jewish communities. About 1 out of 25 individuals is a carrier of the gene and can be accurately identified by means of a simple, inexpensive blood test. 'At risk' couples, i.e. couples of whom both partners are carriers, can be enabled, by means of prenatal diagnosis and selective abortion, to have only unaffected children. Mass screening programmes have been successfully carried out in the USA, Canada and Israel. A discussion of South African Jewish deomgraphy, attitudes to health, and priorities for public health projects, provide the background to a consideration of Tay-Sachs disease prevention in South Africa.
在阿什肯纳兹犹太人群体中，泰-萨克斯病有可能得到预防。大约每25个人中就有1人是该基因的携带者，通过一种简单、廉价的血液检测就能准确识别。“有风险”的夫妇，即双方都是携带者的夫妇，借助产前诊断和选择性流产，可以只生育未受影响的孩子。大规模筛查项目已在美国、加拿大和以色列成功开展。对南非犹太人口统计学、健康观念以及公共卫生项目优先事项的讨论，为在南非预防泰-萨克斯病的思考提供了背景。
