Duval F, Lavarde V
Laboratoire de Parasitologie-Mycologie, Hôpital Broussais, Paris, France.
Pathol Biol (Paris). 1993 May;41(5):469-73.
Fluconazole is a new antifungal drug which is now very often used for the treatment of yeasts infections: mucocutaneous candidosis, systemic candidosis and cryptococcosis. Some resistance seems to occur in clinical practice. It turns out now that it must be necessary to test the drug susceptibility in vitro of the yeast strains isolated from patients. Unfortunately, a current laboratory technique to test this agent doesn't exist. In this work a useful method for Minimal inhibitory concentration (MIC) evaluation in a commercial available broth medium, and a technique for testing fluconazole disks on an agar medium are studied. 150 strains of different yeasts species are tested. A regression curve is performed to correlate the two methods.
氟康唑是一种新型抗真菌药物，目前常用于治疗酵母菌感染：黏膜皮肤念珠菌病、系统性念珠菌病和隐球菌病。在临床实践中似乎出现了一些耐药性。现在发现，对从患者分离出的酵母菌菌株进行体外药敏试验是很有必要的。不幸的是，目前不存在检测这种药物的实验室技术。在这项研究中，研究了一种在市售肉汤培养基中评估最低抑菌浓度（MIC）的有用方法，以及一种在琼脂培养基上检测氟康唑药敏纸片的技术。对150株不同酵母菌种进行了测试。绘制了一条回归曲线以关联这两种方法。
