Martínez-Lavín M, Pineda C, Navarro C, Buendía A, Zabal C
Instituto Nacional de Cardiología Ignacio Chávez, Rheumatology Service, México D.F.
Pediatr Cardiol. 1993 Jul;14(3):181-2. doi: 10.1007/BF00795652.
Patent ductus arteriosus (PDA) is a congenital malformation that has been linked to diverse heritable and chromosomal disorders. Primary hypertrophic osteoarthropathy (HOA) is a rare heritable syndrome in which digital clubbing and periostosis become evident without any underlying illness. The objective of this article is to describe four patients with coexisting PDA and primary HOA. Surgical closure of the ductus showed no effect on the skeletal changes. Primary HOA should be included among the heritable disorders that may be associated with PDA.
动脉导管未闭（PDA）是一种先天性畸形，与多种遗传性和染色体疾病有关。原发性肥厚性骨关节病（HOA）是一种罕见的遗传性综合征，在没有任何潜在疾病的情况下，杵状指和骨膜增生变得明显。本文的目的是描述四名同时患有PDA和原发性HOA的患者。动脉导管的手术闭合对骨骼变化没有影响。原发性HOA应被列入可能与PDA相关的遗传性疾病之中。
