Wananukul S, Huiprasert P, Pongprasit P
Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand.
Pediatr Dermatol. 1993 Sep;10(3):209-13. doi: 10.1111/j.1525-1470.1993.tb00364.x.
To determine whether aeroallergens could induce eczematous lesions, 30 patients with atopic dermatitis were studied in comparison with 30 patients with respiratory atopy without atopic dermatitis. All patients were between 2 and 14 years of age. Patch testing with five aeroallergens--housedust, mite, cockroach, mold mix, and grass mix--was done on skin that was stripped by 10 applications of adhesive tape. Intradermal tests with the same antigens were done on the forearm. In 27 (90%) children with atopic dermatitis, patch testing with aeroallergens induced eczematous lesions at one or more sites. Mite, cockroach, house dust, mold mix, and grass mix caused reactions in 21 (70%), 21 (70%), 19 (63%), 15 (50%), and 13 (43%) patients, respectively. Three patients had a dermatitis flare at the antecubital and popliteal fossae during testing. Only three (10%) atopic children without atopic dermatitis had eczematous lesions, which was significantly different from children with atopic dermatitis (P < 10(-6)). Intradermal skin tests in both groups were not significantly different. This study supports previous reports that aeroallergens plays an important role in causing eczematous skin lesions.
为了确定气传变应原是否能诱发湿疹样皮损，对30例特应性皮炎患者与30例无特应性皮炎的呼吸道特应性患者进行了研究。所有患者年龄在2至14岁之间。对用胶带粘贴10次后剥离的皮肤进行了五种气传变应原（屋尘、螨、蟑螂、混合霉菌和混合草类）的斑贴试验。在前臂进行了相同抗原的皮内试验。在27例（90%）特应性皮炎患儿中，气传变应原斑贴试验在一个或多个部位诱发了湿疹样皮损。螨、蟑螂、屋尘、混合霉菌和混合草类分别使21例（70%）、21例（70%）、19例（63%）、15例（50%）和13例（43%）患者出现反应。3例患者在试验期间肘窝和腘窝处出现皮炎发作。只有3例（10%）无特应性皮炎的特应性儿童有湿疹样皮损，这与特应性皮炎患儿有显著差异（P < 10⁻⁶）。两组的皮内皮肤试验无显著差异。本研究支持先前的报道，即气传变应原在引起湿疹样皮肤损害中起重要作用。
