Khepsheulidze P N
Probl Endokrinol (Mosk). 1993 Jul-Aug;39(4):11-2.
Serum levels of total cholesterol, triglycerides, lipoproteins (VLDL, LDL, HDL) and apoproteins (apo-AI, apo-AII, apo-B) were measured in 112 children (70 boys, 42 girls) aged 6 to 13 with type I diabetes mellitus and healthy controls. Poorly controllable diabetes was associated with elevated concentrations of total cholesterol and low-density lipoproteins C and lowered levels of high-density lipoproteins C, apo AI and apo-AII, while differences in triglyceride, very low density lipoproteins, and apo-B were insignificant. Children with a good metabolic control (HbA1 8.8 +/- 1.2%) had a much more favorable lipid profile. The differences may be explained by lipid-reducing effects of diets and insulin therapy. Deficiency of HDL-C, apo-AI and apo-AII in type I diabetes in children indicates the importance of HDL subclasses and of lipolytic enzymes evaluation for an early detection of atherosclerosis risk.
对112名6至13岁的I型糖尿病儿童（70名男孩，42名女孩）及健康对照者测量了血清总胆固醇、甘油三酯、脂蛋白（极低密度脂蛋白、低密度脂蛋白、高密度脂蛋白）和载脂蛋白（载脂蛋白AI、载脂蛋白AII、载脂蛋白B）的水平。难以控制的糖尿病与总胆固醇和低密度脂蛋白C浓度升高以及高密度脂蛋白C、载脂蛋白AI和载脂蛋白AII水平降低有关，而甘油三酯、极低密度脂蛋白和载脂蛋白B的差异不显著。代谢控制良好（糖化血红蛋白8.8 +/- 1.2%）的儿童血脂情况更为有利。这些差异可能由饮食和胰岛素治疗的降脂作用来解释。儿童I型糖尿病中高密度脂蛋白C、载脂蛋白AI和载脂蛋白AII的缺乏表明，评估高密度脂蛋白亚类和脂解酶对于早期检测动脉粥样硬化风险具有重要意义。
