Babichev V N, Shishkina I V
Probl Endokrinol (Mosk). 1993 Jul-Aug;39(4):42-5.
Effects of temporary hypoinsulinemia induced by streptozotocin in neonatal age on the development of the mechanism of hypothalamic regulation of hypophyseal gonadotropic function in rats were studied. With this aim the authors analyzed the status and functional capacity of feedback system mediating hypothalamic regulation of gonadotropin secretion in female and male rats at the age when this system starts functioning in health. Streptozotocin injection in the neonatal age induced a reduction of estradiol concentration and of estradiol and progesterone-stimulated preovulatory peak of luteinizing hormone (LH) in 28-day-old females and a reduction of LH concentration in 28-day-old castrated males. Reduced estradiol and LH peak were observed in adult females injected streptozotocin during the first week of life and reduced LH level in adult males. These results permit a hypothesis that streptozotocin administration to rats in the neonatal age disturbed the mechanism of hypophyseal gonadotropic function regulation in mature rats.
研究了链脲佐菌素诱导的新生期暂时性低胰岛素血症对大鼠下丘脑调节垂体促性腺功能机制发育的影响。为此，作者分析了雌性和雄性大鼠在该系统开始正常发挥功能的年龄时，介导下丘脑调节促性腺激素分泌的反馈系统的状态和功能能力。新生期注射链脲佐菌素导致28日龄雌性大鼠雌二醇浓度降低，雌二醇和孕酮刺激的促黄体生成素（LH）排卵前峰值降低，以及28日龄去势雄性大鼠LH浓度降低。在出生后第一周注射链脲佐菌素的成年雌性大鼠中观察到雌二醇和LH峰值降低，成年雄性大鼠中LH水平降低。这些结果使我们可以假设，新生期给大鼠注射链脲佐菌素会扰乱成年大鼠垂体促性腺功能的调节机制。
