Dunphy C H, Petruska P J, Martin T W
Department of Pathology, St. Louis University School of Medicine, Missouri.
Mod Pathol. 1993 Jul;6(4):500-4.
A 58-yr-old white woman, with a 9-yr history of non-Hodgkin's lymphoma with recurrences and multi-modality therapy, presents with acute leukemia and residual lymphadenopathy. By flow cytometric analysis, cytochemistry, and cytomorphology, the leukemia is classified as acute myelogenous leukemia (AML), M4, and the lymph nodes are found to contain residual NHL in addition to an AML infiltrate. Immunohistochemistry performed on the lymph nodes correlates with the flow cytometric data. A review of the literature of AML secondary to therapy for non-Hodgkin's lymphoma is also conducted. There are no documented cases in the English literature of simultaneous involvement of lymph nodes by residual lymphoma and an AML infiltrate. Thus, this report is unique in the simultaneous involvement of lymph nodes by residual lymphoma and therapy-related AML. It emphasizes the application and usefulness of flow cytometry and immunohistochemistry in such cases.
一名58岁的白人女性，有9年非霍奇金淋巴瘤病史，经历过复发及多模式治疗，现出现急性白血病和残留淋巴结病。通过流式细胞术分析、细胞化学和细胞形态学检查，该白血病被分类为急性髓系白血病（AML），M4型，且发现淋巴结除有AML浸润外，还含有残留的非霍奇金淋巴瘤。对淋巴结进行的免疫组化检查结果与流式细胞术数据相符。同时还对非霍奇金淋巴瘤治疗后继发性AML的文献进行了综述。英文文献中尚无残留淋巴瘤和AML浸润同时累及淋巴结的记录病例。因此，本报告在残留淋巴瘤和治疗相关AML同时累及淋巴结方面具有独特性。它强调了流式细胞术和免疫组化在此类病例中的应用及实用性。
