Grevelink S A, Youssef D E, Loscalzo J, Lerner E A
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown 02129.
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9155-8. doi: 10.1073/pnas.90.19.9155.
Salivary gland extracts of the deerfly contain a potent inhibitor of platelet aggregation, which assists the insect in obtaining a blood meal. The extract prevents platelet aggregation induced by ADP, thrombin, and collagen and inhibits fibrinogen binding to the glycoprotein IIb/IIIa receptor on platelets. The active component in deerfly salivary gland extract appears to be a protein that is comparatively more potent than the disintegrins present in viper venoms. Isolation and characterization of this protein may provide different directions in therapeutics and studies of normal platelet physiology.
鹿虻的唾液腺提取物含有一种强效的血小板聚集抑制剂，这有助于昆虫获取血餐。该提取物可防止由二磷酸腺苷（ADP）、凝血酶和胶原蛋白诱导的血小板聚集，并抑制纤维蛋白原与血小板上糖蛋白IIb/IIIa受体的结合。鹿虻唾液腺提取物中的活性成分似乎是一种蛋白质，其效力比蝰蛇毒液中的去整合素更强。对这种蛋白质的分离和表征可能会为治疗学和正常血小板生理学研究提供不同的方向。
