Sahgal A, Keith A B
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle-upon-Tyne, U.K.
Pharmacol Biochem Behav. 1993 Aug;45(4):995-1001. doi: 10.1016/0091-3057(93)90155-m.
Rats were trained on a delayed nonmatching to position task, divided into four groups and given the following lesions: (a) SHAM (vehicle injection into nucleus basalis magnocellularis (NBM) and raphé nuclei (RN), (b) RN (5,7-dihydroxytryptamine lesions of raphé, vehicle into NBM), (c) NBM (quisqualic acid lesion of NBM, vehicle into RN), and (d) COMB (lesions of both RN and NBM). RN lesions had no effect on performance measures including accuracy (percent correct), errors of omission, bias, latencies, and magazine response rate. NBM lesions produced delay-independent (nonmnemonic) disruptions, but performance improved over the 20 days' test. The effects of COMB lesions were no worse than NBM lesions alone. The results suggest that (a) the serotonergic system is not essential for performance in this task, (b) NBM lesions transiently impair nonmnemonic aspects of performance, and (c) serotonergic-cholinergic interactions may not be essential for some cognitive processes.
将大鼠训练进行延迟位置不匹配任务，分为四组并给予以下损伤：(a)假手术组（向基底大细胞核（NBM）和中缝核（RN）注射赋形剂），(b) RN组（对中缝核进行5,7-二羟基色胺损伤，向NBM注射赋形剂），(c) NBM组（对NBM进行喹啉酸损伤，向RN注射赋形剂），以及(d)联合组（对RN和NBM都进行损伤）。RN损伤对包括准确率（正确百分比）、漏报错误、偏差、潜伏期和食槽反应率在内的行为指标没有影响。NBM损伤产生与延迟无关（非记忆性）的干扰，但在20天的测试过程中行为表现有所改善。联合损伤的影响并不比单独的NBM损伤更严重。结果表明：(a) 5-羟色胺能系统对该任务的行为表现并非必不可少；(b) NBM损伤会短暂损害行为表现的非记忆方面；(c) 5-羟色胺能-胆碱能相互作用对某些认知过程可能并非必不可少。
