Bidzan L
II Kliniki Chorób Psychicznych AM, Gdańsku.
Psychiatr Pol. 1993 Jul-Aug;27(4):423-30.
During the process of normal ageing significant loss of neural brain cells is known to take place. To a greater or lesser degree, all ageing persons undergo the process which does not deviate in a qualitative sense from the morphological changes observed in the dementias. It is therefore reasonable to assume that the following 3 relationships can occur between normal ageing and the dementias. Firstly, dementia may results directly from the ageing process of the C.N.S. alone. Secondly, a number of diverse factors either augments normal ageing deficits or accelerates the very process. Finally, normal ageing and dementias are assumed to be coincidental. There exists considerable evidence that most dementias are generated by an accelerating rate of ageing of the C.N.S. or by augmentation of the process by diverse factors. The acceptance of the above hypothesis may be beneficial not only from the theoretical point of view but could also produce new treatment techniques and, particularly, assist in preventing Alzheimer's and other dementias.
在正常衰老过程中，已知会发生大量神经脑细胞的损失。或多或少，所有老年人都会经历这个过程，从质的方面来看，这个过程与在痴呆症中观察到的形态学变化并无偏差。因此，合理的假设是，正常衰老和痴呆症之间可能存在以下三种关系。首先，痴呆症可能仅直接源于中枢神经系统的衰老过程。其次，一些不同的因素要么加剧正常衰老缺陷，要么加速这个过程本身。最后，正常衰老和痴呆症被认为是巧合。有大量证据表明，大多数痴呆症是由中枢神经系统加速衰老或由各种因素加剧这个过程所导致的。接受上述假设不仅从理论角度来看可能有益，还可能产生新的治疗技术，特别是有助于预防阿尔茨海默病和其他痴呆症。
