Keks N A, Copolov D L, McKenzie D P, Kulkarni J, Hassett A, Matheson B, Hill C, Mackie B, Singh B, Hirt J
Department of Psychological Medicine, Monash University, Prahan, Victoria, Australia.
Psychiatry Res. 1993 Jul;48(1):79-90. doi: 10.1016/0165-1781(93)90115-w.
The role of alpha 2-adrenergic receptor sensitivity in schizophrenia was examined by measuring growth hormone (GH) response after the intravenous administration of clonidine (1.3 micrograms/kg) in 26 healthy control subjects and 26 neuroleptic-free, acutely psychotic patients with at least 1 out of 11 possible diagnoses of schizophrenia derived from a multidiagnostic psychopathological assessment. GH responses were significantly (0.01) lower than control values in schizophrenias defined by E. Bleuler, M. Bleuler, Schneider, Langfeldt, Taylor and Abrams, and Cloninger, but not in DSM-III, World Health Organization, Feighner, Kraepelian, and Research Diagnostic Criteria (RDC) schizophrenias. Eight patients with RDC schizoaffective disorder also had a blunted response. However, there were no correlations with any symptom measures. There were no differences between paranoid and nonparanoid patients, although there was a significant difference between nonparanoid patients and control subjects. These findings support the presence of noradrenergic dysfunction in some patients within the schizophrenia syndrome, possibly those whose illnesses have an affective component. The study also illustrates the need for simultaneous investigation of several different sets of diagnostic criteria for schizophrenia in neurobiological research.
通过对26名健康对照者和26名未使用抗精神病药物、急性精神病性发作且在多诊断精神病理学评估中至少符合11种可能的精神分裂症诊断标准之一的患者静脉注射可乐定（1.3微克/千克）后测量生长激素（GH）反应，来研究α2-肾上腺素能受体敏感性在精神分裂症中的作用。在由E. 布鲁勒、M. 布鲁勒、施耐德、朗费尔特、泰勒和艾布拉姆斯以及克隆宁格定义的精神分裂症患者中，GH反应显著（P<0.01）低于对照值，但在DSM-III、世界卫生组织、费格纳、克雷佩林以及研究诊断标准（RDC）定义的精神分裂症患者中并非如此。8名患有RDC分裂情感性障碍的患者也有反应迟钝的情况。然而，与任何症状指标均无相关性。偏执型和非偏执型患者之间没有差异，尽管非偏执型患者与对照者之间存在显著差异。这些发现支持了精神分裂症综合征中的一些患者存在去甲肾上腺素能功能障碍，可能是那些疾病伴有情感成分的患者。该研究还表明在神经生物学研究中需要同时对几种不同的精神分裂症诊断标准进行研究。
