Brambilla F, Marini S, Saito A, Fassone G, Picardi A, Nerozzi D, Pancheri P
Center of Psychoneuroendocrinology, Ospedale Psichiatrico Pini, Milano, Italy.
Psychiatry Res. 1994 Sep;53(3):231-42. doi: 10.1016/0165-1781(94)90052-3.
Growth hormone (GH) and prolactin (PRL) responses to the acute administration of clonidine (150 micrograms) and apomorphine (0.5 mg) were investigated in parallel in 20 drug-free subchronic and chronic schizophrenic patients and in nine control subjects. Neither basal levels of the two hormones nor their mean responses to both stimuli differed significantly between the two groups. However, eight patients had blunted GH responses to clonidine and seven to apomorphine; only two patients showed blunted GH responses to both stimuli. The blunted GH response to apomorphine correlated with the chronicity of the disorder. A greater than normal GH response to clonidine stimulation was observed in paranoid patients. Significant correlations were observed between negative symptoms and GH responses to clonidine (negative), between negative symptoms and PRL responses to apomorphine (positive), and between positive symptoms and PRL responses to apomorphine (negative).
在20名未服用药物的亚慢性和慢性精神分裂症患者以及9名对照受试者中，同时研究了生长激素（GH）和催乳素（PRL）对急性给予可乐定（150微克）和阿扑吗啡（0.5毫克）的反应。两组之间这两种激素的基础水平及其对两种刺激的平均反应均无显著差异。然而，8名患者对可乐定的GH反应迟钝，7名对阿扑吗啡的反应迟钝；只有2名患者对两种刺激的GH反应均迟钝。对阿扑吗啡的GH反应迟钝与疾病的慢性程度相关。在偏执型患者中观察到对可乐定刺激的GH反应高于正常。在阴性症状与对可乐定的GH反应之间（呈负相关）、阴性症状与对阿扑吗啡的PRL反应之间（呈正相关）以及阳性症状与对阿扑吗啡的PRL反应之间（呈负相关）观察到显著相关性。
