Ishizaki A, Kubota M, Fueki N, Shinozaki M, Kurata K, Takei M, Sakamoto K
Metropolitan Medical Center of the Severely Handicapped, Fuchu, Tokyo.
No To Hattatsu. 1993 Jan;25(1):26-32.
A long-term observation has been made in 58 patients (30 males and 28 females) with severe sequelae of neonatal anoxic encephalopathy. They aged from 8 months to 65 years. All of them had motor disturbances and profound mental retardation. Motor function was improved in 4 patients with aging. In contrast, motor activity deteriorated in 11 cases, of which 4 showed a mental regression. Among them, patients who had originally better motor ability than sitting were likely to deteriorate by uncontrollable epilepsy and/or excessive administration of anticonvulsants. Regression of the patients with worse motor ability like bedridden appeared to attributable hypertonia of muscles and bodily deformation. Fifteen cases showed an exacerbation of general condition which originated predominantly to respiratory distress. Twelve patients died including 6 exacerbated cases. Exacerbation or death may have occurred frequently in specific periods of infancy, adolescence and youth with the patients who showed very low motor function such as bedridden and no locomotion.
对58例（男30例，女28例）新生儿缺氧缺血性脑病重度后遗症患者进行了长期观察。他们的年龄从8个月到65岁不等。所有患者均有运动障碍和重度智力发育迟缓。4例患者随着年龄增长运动功能有所改善。相比之下，11例患者运动活动恶化，其中4例出现智力倒退。其中，原本运动能力优于坐位的患者可能因无法控制的癫痫发作和/或抗惊厥药物使用过量而恶化。运动能力较差如卧床不起的患者病情倒退似乎归因于肌肉张力亢进和身体变形。15例患者全身状况恶化，主要源于呼吸窘迫。12例患者死亡，其中6例为病情恶化病例。在婴儿期、青春期和青年期的特定阶段，对于运动功能极低如卧床不起且无法活动的患者，病情恶化或死亡可能经常发生。
