Nishihara K, Nagoshi M, Tsuneyoshi M, Yamaguchi K, Hayashi I
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Cancer. 1993 Jan 1;71(1):82-92. doi: 10.1002/1097-0142(19930101)71:1<82::aid-cncr2820710114>3.0.co;2-y.
Although the biologic characteristics of papillary cystic tumors (PCT) generally indicate a good prognosis, a malignant form has been reported.
Twenty-two examples of PCT were examined to assess their malignant potential by histologic, flow cytometric, and immunohistochemical studies.
Three had hepatic, peritoneal, and/or lymph node metastases (metastasizing tumors [MT]); the other 19 PCT had no such metastatic features (nonmetastasizing tumors [NMT]). Venous invasion was detected in all three MT and two NMT. Compared with the 19 NMT, the MT had a higher nuclear grade and more prominent necrobiotic nests characterized by aggregates of cells with pyknotic nuclei and eosinophilic cytoplasm. In the flow cytometric analysis of cellular DNA content, one MT was aneuploid, and eight NMT were diploid. Immunohistochemically, there was no difference between the MT and NMT.
These results support the assumption that venous invasion, nuclear grade, and prominent necrobiotic nests are useful as histologic parameters to detect the malignant potential of PCT.
尽管乳头状囊性肿瘤（PCT）的生物学特性通常提示预后良好，但已有恶性形式的报道。
对22例PCT进行检查，通过组织学、流式细胞术和免疫组织化学研究评估其恶性潜能。
3例有肝、腹膜和/或淋巴结转移（转移瘤[MT]）；其他19例PCT无此类转移特征（非转移瘤[NMT]）。在所有3例MT和2例NMT中均检测到静脉侵犯。与19例NMT相比，MT的核分级更高，坏死巢更明显，其特征为细胞核固缩和嗜酸性细胞质的细胞聚集。在细胞DNA含量的流式细胞术分析中，1例MT为非整倍体，8例NMT为二倍体。免疫组织化学显示，MT和NMT之间无差异。
这些结果支持以下假设，即静脉侵犯、核分级和明显的坏死巢可作为检测PCT恶性潜能的有用组织学参数。
